Protein Summary
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
- ENST00000308580
- ENSP00000308753
- ENSG00000138594
- UTMOD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.99 | ||
disease perturbation | 0.96 | ||
kinase perturbation | 0.95 | ||
transcription factor binding site profile | 0.84 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 136 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 136 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (112)
SCIN
Novelty: 0.0080322
p_int: 0.999999976
p_ni: 1.7e-8
p_wrong: 8e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
LRRFIP1
Novelty: 0.02584638
p_int: 0.999999728
p_ni: 2.72e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
POTEI
Novelty: 0.41311202
p_int: 0.999999211
p_ni: 7.89e-7
Score: 0.26
Data Source: BioPlex,STRINGDB
MYO5B
Novelty: 0.01302142
p_int: 0.999999094
p_ni: 9.06e-7
Score: 0.171
Data Source: BioPlex,STRINGDB
INF2
Novelty: 0.00978892
p_int: 0.999996276
p_ni: 0.000003475
p_wrong: 2.49e-7
Score: 0.265
Data Source: BioPlex,STRINGDB
ALAS1
Family: Enzyme
Novelty: 0.00965779
p_int: 0.999994571
p_ni: 0.000005426
p_wrong: 3e-9
Data Source: BioPlex
SVIL
Novelty: 0.03007571
p_int: 0.999989469
p_ni: 3.18e-7
p_wrong: 0.000010213
Score: 0.301
Data Source: BioPlex,STRINGDB
FLII
Novelty: 0.00200219
p_int: 0.999967533
p_ni: 0.000032467
Score: 0.419
Data Source: BioPlex,STRINGDB
LRRFIP2
Novelty: 0.15492934
p_int: 0.999966621
p_ni: 0.000033379
Score: 0.299
Data Source: BioPlex,STRINGDB
ACTA2
Novelty: 0.00199354
p_int: 0.999691923
p_ni: 0.000308077
Score: 0.386
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Muscle contraction | ||||
Reactome | Striated Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Muscle contraction | ||||
Striated Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
cognitive function measurement | 2 | 1 | 2 | 48.5 | |||||
self reported educational attainment | 1 | 1 | 1 | 46.9 | |||||
body height | 1 | 1 | 1 | 40.7 | |||||
intelligence | 2 | 2 | 1 | 5.4 | 39.5 | ||||
frailty measurement | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
cognitive function measurement | 2 | 48.5 | |||||
self reported educational attainment | 1 | 46.9 | |||||
body height | 1 | 40.7 | |||||
intelligence | 1 | 5.4 | 39.5 | ||||
frailty measurement | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tropomodulin 3 | VGNC:2467 | 467683 | |||||
Macaque | tropomodulin 3 | 694478 | ||||||
Mouse | MGI:1355315 | 50875 | ||||||
Rat | RGD:1311030 | 300838 | ||||||
Dog | tropomodulin 3 | VGNC:47625 | 487554 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tropomodulin 3 | |||||
Macaque | tropomodulin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tropomodulin 3 | |||||
Publication Statistics
PubMed Score 24.00
PubMed score by year
PubTator Score 13.39
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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