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Tbio
TMOD3
Tropomodulin-3

Protein Summary
Description
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308580
  • ENSP00000308753
  • ENSG00000138594

Symbol
  • UTMOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.96
kinase perturbation
0.95
transcription factor binding site profile
0.84
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
SCIN
Tbio
Novelty:  0.0080322
p_int:  0.999999976
p_ni:  1.7e-8
p_wrong:  8e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
LRRFIP1
Tbio
Novelty:  0.02584638
p_int:  0.999999728
p_ni:  2.72e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999999211
p_ni:  7.89e-7
Score:  0.26
Data Source:  BioPlex,STRINGDB
MYO5B
Tbio
Novelty:  0.01302142
p_int:  0.999999094
p_ni:  9.06e-7
Score:  0.171
Data Source:  BioPlex,STRINGDB
INF2
Tbio
Novelty:  0.00978892
p_int:  0.999996276
p_ni:  0.000003475
p_wrong:  2.49e-7
Score:  0.265
Data Source:  BioPlex,STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
p_int:  0.999994571
p_ni:  0.000005426
p_wrong:  3e-9
Data Source:  BioPlex
SVIL
Tbio
Novelty:  0.03007571
p_int:  0.999989469
p_ni:  3.18e-7
p_wrong:  0.000010213
Score:  0.301
Data Source:  BioPlex,STRINGDB
FLII
Tbio
Novelty:  0.00200219
p_int:  0.999967533
p_ni:  0.000032467
Score:  0.419
Data Source:  BioPlex,STRINGDB
LRRFIP2
Tbio
Novelty:  0.15492934
p_int:  0.999966621
p_ni:  0.000033379
Score:  0.299
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.999691923
p_ni:  0.000308077
Score:  0.386
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
1
2
48.5
self reported educational attainment
1
1
1
46.9
body height
1
1
1
40.7
intelligence
2
2
1
5.4
39.5
frailty measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
2
48.5
self reported educational attainment
1
46.9
body height
1
40.7
intelligence
1
5.4
39.5
frailty measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tropomodulin 3
VGNC:2467
467683
Macaque
tropomodulin 3
694478
Mouse
MGI:1355315
50875
Rat
RGD:1311030
300838
Dog
tropomodulin 3
VGNC:47625
487554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tropomodulin 3
Macaque
tropomodulin 3
Mouse
Rat
Dog
tropomodulin 3
Publication Statistics
PubMed Score 24.00
PubMed score by year
PubTator Score 13.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title