Tbio TMOD3 Tropomodulin-3

Protein Summary

Description

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Uniprot Accession IDs

• Q9NYL9
• B2R6G7
• Q9NT43
• Q9NZR0

Gene Name

• TMOD3

Ensembl ID

• ENST00000308580
• ENSP00000308753
• ENSG00000138594

Symbol

• UTMOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
disease perturbation	0.96
kinase perturbation	0.95
transcription factor binding site profile	0.84
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Tropomodulin-3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Tropomodulin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (112)

Explore Interacting Targets

1 – 10 of 112

• See Interactions on String-DB

SCIN

Tbio

Novelty:  0.0080322

p_int:  0.999999976

p_ni:  1.7e-8

p_wrong:  8e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

LRRFIP1

Tbio

Novelty:  0.02584638

p_int:  0.999999728

p_ni:  2.72e-7

Score:  0.237

Data Source:  BioPlex,STRINGDB

POTEI

Tdark

Novelty:  0.41311202

p_int:  0.999999211

p_ni:  7.89e-7

Score:  0.26

Data Source:  BioPlex,STRINGDB

MYO5B

Tbio

Novelty:  0.01302142

p_int:  0.999999094

p_ni:  9.06e-7

Score:  0.171

Data Source:  BioPlex,STRINGDB

INF2

Tbio

Novelty:  0.00978892

p_int:  0.999996276

p_ni:  0.000003475

p_wrong:  2.49e-7

Score:  0.265

Data Source:  BioPlex,STRINGDB

ALAS1

Tclin

Family:  Enzyme

Novelty:  0.00965779

p_int:  0.999994571

p_ni:  0.000005426

p_wrong:  3e-9

Data Source:  BioPlex

SVIL

Tbio

Novelty:  0.03007571

p_int:  0.999989469

p_ni:  3.18e-7

p_wrong:  0.000010213

Score:  0.301

Data Source:  BioPlex,STRINGDB

FLII

Tbio

Novelty:  0.00200219

p_int:  0.999967533

p_ni:  0.000032467

Score:  0.419

Data Source:  BioPlex,STRINGDB

LRRFIP2

Tbio

Novelty:  0.15492934

p_int:  0.999966621

p_ni:  0.000033379

Score:  0.299

Data Source:  BioPlex,STRINGDB

ACTA2

Tbio

Novelty:  0.00199354

p_int:  0.999691923

p_ni:  0.000308077

Score:  0.386

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Muscle contraction (R-HSA-397014)

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Striated Muscle Contraction	34 targets	R-HSA-390522

Name	Explore in Pharos	Explore in Source
Muscle contraction	202 targets	R-HSA-397014
Striated Muscle Contraction	34 targets	R-HSA-390522

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (3)

Processes (5)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
cadherin binding involved in cell-cell adhesion	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
tropomyosin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cognitive function measurement	EFO_0008354	2	1	2		48.5
self reported educational attainment	EFO_0004784	1	1	1		46.9
body height	EFO_0004339	1	1	1		40.7
intelligence	EFO_0004337	2	2	1	5.4	39.5
frailty measurement	EFO_0009885	1	1	1		17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cognitive function measurement	EFO_0008354	2		48.5
self reported educational attainment	EFO_0004784	1		46.9
body height	EFO_0004339	1		40.7
intelligence	EFO_0004337	1	5.4	39.5
frailty measurement	EFO_0009885	1		17.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
body height
cognitive function measurement
frailty measurement
intelligence
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tropomodulin 3	VGNC:2467	467683
Macaque	tropomodulin 3		694478
Mouse	tropomodulin 3	MGI:1355315	50875
Rat	tropomodulin 3	RGD:1311030	300838
Dog	tropomodulin 3	VGNC:47625	487554

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tropomodulin 3
Macaque	tropomodulin 3
Mouse	tropomodulin 3
Rat	tropomodulin 3
Dog	tropomodulin 3

Publication Statistics

PubMed Score 24.00

PubMed score by year

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PubTator Score 13.39

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (6)

Items per page:

10

0 of 0

PMID	Year	Title