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Tbio
TMLHE
Trimethyllysine dioxygenase, mitochondrial

Protein Summary
Description
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983). This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334398
  • ENSP00000335261
  • ENSG00000185973
  • ENST00000369439
  • ENSP00000358447

Symbol
  • TMLH
  • TMLD
  • TMLH
  • BBOX2
  • AUTSX6
  • TMLHED
  • XAP130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
molecular function
0.79
tissue sample
0.69
interacting protein
0.63
microRNA
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.04   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.04   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.88421589
p_ni:  0.115060802
p_wrong:  0.000723308
Score:  0.155
Data Source:  BioPlex,STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.789247287
p_ni:  0.210752713
Data Source:  BioPlex
STIM2
Tbio
Novelty:  0.00446493
p_int:  0.785664641
p_ni:  0.214335359
Score:  0.39
Data Source:  BioPlex,STRINGDB
ALDH9A1
Tbio
Family:  Enzyme
Novelty:  0.01688006
Score:  0.862
Data Source:  STRINGDB
TRIM5
Tbio
Novelty:  0.00289445
Score:  0.809
Data Source:  STRINGDB
TRIM36
Tbio
Family:  Enzyme
Novelty:  0.06724803
Score:  0.8
Data Source:  STRINGDB
TRAT1
Tbio
Novelty:  0.0015709
Score:  0.756
Data Source:  STRINGDB
TRIM45
Tbio
Novelty:  0.03874681
Score:  0.755
Data Source:  STRINGDB
TRIM17
Tbio
Family:  Enzyme
Novelty:  0.00984948
Score:  0.733
Data Source:  STRINGDB
TRIM31
Tbio
Family:  Enzyme
Novelty:  0.00331706
Score:  0.71
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Carnitine synthesis (R-HSA-71262)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carnitine synthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Carnitine synthesis
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
2
75
body mass index
1
1
1
72.3
low density lipoprotein cholesterol measurement
1
1
2
71.3
triglyceride measurement
1
1
2
54.4
factor VIII measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
75
body mass index
1
72.3
low density lipoprotein cholesterol measurement
2
71.3
triglyceride measurement
2
54.4
factor VIII measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
trimethyllysine hydroxylase, epsilon
703711
Mouse
MGI:2180203
192289
Rat
RGD:620629
170898
Dog
trimethyllysine hydroxylase, epsilon
VGNC:47622
481090
Horse
trimethyllysine hydroxylase, epsilon
VGNC:24331
100062170
Species
Name
OMA
EggNOG
Inparanoid
Macaque
trimethyllysine hydroxylase, epsilon
Mouse
Rat
Dog
trimethyllysine hydroxylase, epsilon
Horse
trimethyllysine hydroxylase, epsilon
Publication Statistics
PubMed Score 42.04
PubMed score by year
PubTator Score 19.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title