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Tbio
TMIGD1
Transmembrane and immunoglobulin domain-containing protein 1

Protein Summary
Description
May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328886
  • ENSP00000332404
  • ENSG00000182271
  • ENST00000538566
  • ENSP00000446118

Symbol
  • TMIGD
  • TMIGD
  • UNQ9372
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
tissue sample
0.59
protein domain
0.58
cell line
0.55
gene perturbation
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
GUCA2A
Tbio
Novelty:  0.00856211
Score:  0.837
Data Source:  STRINGDB
HHLA2
Tbio
Novelty:  0.06299917
Score:  0.728
Data Source:  STRINGDB
GUCA2B
Tbio
Family:  Enzyme
Novelty:  0.02002363
Score:  0.728
Data Source:  STRINGDB
MRM3
Tbio
Family:  Enzyme
Novelty:  0.06515109
Score:  0.719
Data Source:  STRINGDB
DPH1
Tbio
Novelty:  0.02296024
Score:  0.714
Data Source:  STRINGDB
PITPNM3
Tbio
Novelty:  0.02122312
Score:  0.704
Data Source:  STRINGDB
RSKR
Tdark
Family:  Kinase
Novelty:  1.64952942
Score:  0.696
Data Source:  STRINGDB
KIAA0753
Tdark
Novelty:  0.00878365
Score:  0.692
Data Source:  STRINGDB
CLCA1
Tbio
Family:  IC
Novelty:  0.01111462
Score:  0.677
Data Source:  STRINGDB
OTOP2
Tbio
Novelty:  0.40535125
Score:  0.657
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
54
sex hormone-binding globulin measurement
2
1
2
46.3
total cholesterol measurement
1
2
2
43.5
visceral adipose tissue measurement
1
1
1
38.2
appendicular lean mass
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
54
sex hormone-binding globulin measurement
2
46.3
total cholesterol measurement
2
43.5
visceral adipose tissue measurement
1
38.2
appendicular lean mass
1
20.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and immunoglobulin domain containing 1
VGNC:14206
735646
Macaque
transmembrane and immunoglobulin domain containing 1
712350
Mouse
MGI:1913851
66601
Rat
RGD:1307444
363654
Dog
transmembrane and immunoglobulin domain containing 1
611097
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and immunoglobulin domain containing 1
Macaque
transmembrane and immunoglobulin domain containing 1
Mouse
Rat
Dog
transmembrane and immunoglobulin domain containing 1
Publication Statistics
PubMed Score 10.29
PubMed score by year
PubTator Score 2.34
PubTator score by year
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Related Publications
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PMID
Year
Title