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Tbio
TMIE
Transmembrane inner ear expressed protein

Protein Summary
Description
Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326431
  • ENSP00000324775
  • ENSG00000181585
  • ENST00000643606
  • ENSP00000494576

Symbol
  • DFNB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
tissue sample
0.56
tissue
0.55
microRNA
0.46
chemical
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
C2CD5
Tbio
Novelty:  0.40144687
p_int:  0.961407187
p_ni:  0.03858158
p_wrong:  0.000011233
Data Source:  BioPlex
TRIM3
Tbio
Novelty:  0.0188159
p_int:  0.933569403
p_ni:  0.066430482
p_wrong:  1.15e-7
Data Source:  BioPlex
FIBP
Tbio
Novelty:  0.11312115
p_int:  0.851232921
p_ni:  0.003596147
p_wrong:  0.145170933
Data Source:  BioPlex
TMC1
Tbio
Family:  IC
Novelty:  0.00609628
Score:  0.921
Data Source:  STRINGDB
TMC2
Tbio
Family:  IC
Novelty:  0.03655557
Score:  0.882
Data Source:  STRINGDB
LHFPL5
Tbio
Novelty:  0.03689538
Score:  0.88
Data Source:  STRINGDB
PCDH15
Tbio
Novelty:  0.0097699
Score:  0.858
Data Source:  STRINGDB
MYO7A
Tbio
Novelty:  0.00314435
Score:  0.781
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.747
Data Source:  STRINGDB
CDH23
Tbio
Novelty:  0.00588227
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
1
1
82.5
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
82.5
1
1.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane inner ear
VGNC:2616
740562
Macaque
transmembrane inner ear
712706
Mouse
MGI:2159400
20776
Rat
RGD:1562523
501061
Dog
transmembrane inner ear
VGNC:47621
609350
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane inner ear
Macaque
transmembrane inner ear
Mouse
Rat
Dog
transmembrane inner ear
Publication Statistics
PubMed Score 35.85
PubMed score by year
PubTator Score 13.15
PubTator score by year
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Related Publications
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PMID
Year
Title