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Tbio
TMF1
TATA element modulatory factor

Protein Summary
Description
Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398559
  • ENSP00000381567
  • ENSG00000144747
  • ENST00000646708
  • ENSP00000494067

Symbol
  • ARA160
  • TMF
  • ARA160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
microRNA
0.86
transcription factor perturbation
0.84
histone modification site profile
0.66
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.64   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.64   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999999577
p_ni:  4.22e-7
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.999992869
p_ni:  0.000004146
p_wrong:  0.000002985
Score:  0.179
Data Source:  BioPlex,STRINGDB
TCP10L2
Tdark
Novelty:  4.42416561
p_int:  0.999987008
p_ni:  0.000012989
p_wrong:  3e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
BSPRY
Tdark
Novelty:  0.38200913
p_int:  0.9999808
p_ni:  0.000019191
p_wrong:  9e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
AP1M2
Tbio
Novelty:  0.02984354
p_int:  0.99735729
p_ni:  0.000559424
p_wrong:  0.002083287
Score:  0.232
Data Source:  BioPlex,STRINGDB
RAB6A
Tchem
Family:  Enzyme
Novelty:  0.00546034
Score:  0.985
Data Source:  STRINGDB
GOLGA1
Tbio
Novelty:  0.02142224
Score:  0.957
Data Source:  STRINGDB
GCC1
Tbio
Novelty:  0.0844824
Score:  0.952
Data Source:  STRINGDB
COG3
Tbio
Novelty:  0.02746711
Score:  0.952
Data Source:  STRINGDB
GCC2
Tbio
Novelty:  0.03809539
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
74.7
sex hormone-binding globulin measurement
3
2
3
57.6
diet measurement
1
1
1
29
mean corpuscular hemoglobin concentration
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
74.7
sex hormone-binding globulin measurement
3
57.6
diet measurement
1
29
mean corpuscular hemoglobin concentration
1
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA element modulatory factor 1
VGNC:12213
470844
Macaque
TATA element modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:11870]
Mouse
MGI:2684999
232286
Rat
RGD:620551
114206
Dog
TATA element modulatory factor 1
VGNC:47620
476561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA element modulatory factor 1
Macaque
TATA element modulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:11870]
Mouse
Rat
Dog
TATA element modulatory factor 1
Publication Statistics
PubMed Score 37.64
PubMed score by year
PubTator Score 28.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title