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Tdark
TMEM9B
Transmembrane protein 9B

Protein Summary
Description
Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309134
  • ENSP00000311842
  • ENSG00000175348
  • ENST00000525069
  • ENSP00000431487
  • ENST00000534025
  • ENSP00000433361

Symbol
  • C11orf15
  • C11orf15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.93
histone modification site profile
0.84
kinase perturbation
0.84
microRNA
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
CLCN3
Tchem
Family:  IC
Novelty:  0.00416196
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.677
Data Source:  BioPlex,STRINGDB
CLCN5
Tbio
Family:  IC
Novelty:  0.00419772
p_int:  0.999999925
p_ni:  1.8e-8
p_wrong:  5.7e-8
Score:  0.475
Data Source:  BioPlex,STRINGDB
DNAJC13
Tbio
Novelty:  0.03251995
p_int:  0.999998619
p_ni:  0.000001381
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.999995479
p_ni:  8e-9
p_wrong:  0.000004513
Data Source:  BioPlex
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.998422985
p_ni:  0.000008586
p_wrong:  0.001568429
Data Source:  BioPlex
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.997295543
p_ni:  0.002704457
Score:  0.171
Data Source:  BioPlex,STRINGDB
ABCB9
Tbio
Family:  Transporter
Novelty:  0.02217672
p_int:  0.996579952
p_ni:  0.003342134
p_wrong:  0.000077914
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.993422741
p_ni:  0.006577258
p_wrong:  1e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.971506186
p_ni:  0.000039547
p_wrong:  0.028454267
Data Source:  BioPlex
DCAKD
Tdark
Family:  Enzyme
Novelty:  1.5418995
p_int:  0.96391082
p_ni:  0.03608918
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
92.3
heel bone mineral density
3
2
5
90.9
alkaline phosphatase measurement
2
2
1
9.9
89.9
hemoglobin measurement
1
1
1
83.8
red blood cell density measurement
1
1
1
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
92.3
heel bone mineral density
5
90.9
alkaline phosphatase measurement
1
9.9
89.9
hemoglobin measurement
1
83.8
red blood cell density measurement
1
81.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TMEM9 domain family member B
VGNC:6547
451732
Mouse
MGI:1915254
56786
Rat
RGD:1310775
293415
Dog
TMEM9 domain family member B
VGNC:47619
476843
Horse
TMEM9 domain family member B
VGNC:24329
100071051
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TMEM9 domain family member B
Mouse
Rat
Dog
TMEM9 domain family member B
Horse
TMEM9 domain family member B
Publication Statistics
PubMed Score 1.65
PubMed score by year
PubTator Score 0.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title