Tdark TMEM9B Transmembrane protein 9B

Protein Summary

Description

Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.

Uniprot Accession IDs

• Q9NQ34
• Q7Z649

Gene Name

• TMEM9B

Ensembl ID

• ENST00000309134
• ENSP00000311842
• ENSG00000175348
• ENST00000525069
• ENSP00000431487
• ENST00000534025
• ENSP00000433361

Symbol

• C11orf15
• C11orf15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
disease perturbation	0.93
histone modification site profile	0.84
kinase perturbation	0.84
microRNA	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 18   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (31)

Explore Interacting Targets

1 – 10 of 31

• See Interactions on String-DB

CLCN3

Tchem

Family:  IC

Novelty:  0.00416196

p_int:  0.999999957

p_ni:  4.3e-8

Score:  0.677

Data Source:  BioPlex,STRINGDB

CLCN5

Tbio

Family:  IC

Novelty:  0.00419772

p_int:  0.999999925

p_ni:  1.8e-8

p_wrong:  5.7e-8

Score:  0.475

Data Source:  BioPlex,STRINGDB

DNAJC13

Tbio

Novelty:  0.03251995

p_int:  0.999998619

p_ni:  0.000001381

Data Source:  BioPlex

TMEM9

Tbio

Novelty:  0.06916197

p_int:  0.999995479

p_ni:  8e-9

p_wrong:  0.000004513

Data Source:  BioPlex

TRDN

Tbio

Novelty:  0.00501554

p_int:  0.998422985

p_ni:  0.000008586

p_wrong:  0.001568429

Data Source:  BioPlex

BIRC2

Tchem

Novelty:  0.00199701

p_int:  0.997295543

p_ni:  0.002704457

Score:  0.171

Data Source:  BioPlex,STRINGDB

ABCB9

Tbio

Family:  Transporter

Novelty:  0.02217672

p_int:  0.996579952

p_ni:  0.003342134

p_wrong:  0.000077914

Data Source:  BioPlex

DNM3

Tbio

Novelty:  0.02365643

p_int:  0.993422741

p_ni:  0.006577258

p_wrong:  1e-9

Score:  0.19

Data Source:  BioPlex,STRINGDB

GGA1

Tbio

Novelty:  0.00866392

p_int:  0.971506186

p_ni:  0.000039547

p_wrong:  0.028454267

Data Source:  BioPlex

DCAKD

Tdark

Family:  Enzyme

Novelty:  1.5418995

p_int:  0.96391082

p_ni:  0.03608918

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Components (3)

Processes (1)

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1 – 3 of 3

GO Term	Evidence	Assigned by
early endosome membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
lysosomal membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	2	2	2		92.3
heel bone mineral density	EFO_0009270	3	2	5		90.9
alkaline phosphatase measurement	EFO_0004533	2	2	1	9.9	89.9
hemoglobin measurement	EFO_0004509	1	1	1		83.8
red blood cell density measurement	EFO_0007978	1	1	1		81.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	2		92.3
heel bone mineral density	EFO_0009270	5		90.9
alkaline phosphatase measurement	EFO_0004533	1	9.9	89.9
hemoglobin measurement	EFO_0004509	1		83.8
red blood cell density measurement	EFO_0007978	1		81.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Direct protein sequencing
Endosome
Glycoprotein
Lysosome
Membrane
Phosphoprotein
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
BMI-adjusted waist-hip ratio
heel bone mineral density
hematocrit
hemoglobin measurement
hip circumference
red blood cell density measurement
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	TMEM9 domain family member B	VGNC:6547	451732
Mouse	TMEM9 domain family, member B	MGI:1915254	56786
Rat	TMEM9 domain family, member B	RGD:1310775	293415
Dog	TMEM9 domain family member B	VGNC:47619	476843
Horse	TMEM9 domain family member B	VGNC:24329	100071051

Species	Name	OMA	EggNOG	Inparanoid
Chimp	TMEM9 domain family member B
Mouse	TMEM9 domain family, member B
Rat	TMEM9 domain family, member B
Dog	TMEM9 domain family member B
Horse	TMEM9 domain family member B

Publication Statistics

PubMed Score 1.65

PubMed score by year

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PubTator Score 0.37

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title