Tdark TMEM9B Transmembrane protein 9B

Protein Summary

Description

Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.

Uniprot Accession IDs

• Q9NQ34
• Q7Z649

Gene Name

• TMEM9B

Ensembl ID

• ENST00000309134
• ENSP00000311842
• ENSG00000175348
• ENST00000525069
• ENSP00000431487
• ENST00000534025
• ENSP00000433361

Symbol

• C11orf15
• C11orf15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
disease perturbation	0.93
histone modification site profile	0.84
kinase perturbation	0.84
microRNA	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.26   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 18   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.26   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0