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Tbio
TMEM98
Transmembrane protein 98

Protein Summary
Description
This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394642
  • ENSP00000378138
  • ENSG00000006042
  • ENST00000579849
  • ENSP00000463245

Symbol
  • TADA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.61
small molecule perturbation
0.58
tissue sample
0.58
PubMedID
0.55
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.22   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.22   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.999879649
p_ni:  0.000120306
p_wrong:  4.5e-8
Data Source:  BioPlex
VAMP8
Tbio
Novelty:  0.01083228
p_int:  0.997881343
p_ni:  0.001982802
p_wrong:  0.000135854
Data Source:  BioPlex
STX6
Tbio
Novelty:  0.01494028
p_int:  0.992361268
p_ni:  0.004837479
p_wrong:  0.002801252
Data Source:  BioPlex
STX7
Tbio
Novelty:  0.03109969
p_int:  0.969839593
p_ni:  0.030153731
p_wrong:  0.000006676
Data Source:  BioPlex
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.950530128
p_ni:  0.048476933
p_wrong:  0.000992939
Data Source:  BioPlex
ERGIC2
Tbio
Novelty:  0.08610944
p_int:  0.939679381
p_ni:  0.059367478
p_wrong:  0.000953141
Data Source:  BioPlex
STX8
Tbio
Novelty:  0.01083752
p_int:  0.907402049
p_ni:  0.086732832
p_wrong:  0.005865119
Data Source:  BioPlex
PTPRU
Tbio
Family:  Enzyme
Novelty:  0.0090218
p_int:  0.906951564
p_ni:  0.093048436
Data Source:  BioPlex
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.898947684
p_ni:  0.092593997
p_wrong:  0.008458319
Data Source:  BioPlex
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.874018467
p_ni:  0.089458781
p_wrong:  0.036522752
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
3
2
3
8.6
86.9
red blood cell distribution width
2
2
2
83.9
Myopia
2
2
0
4.8
78.7
reticulocyte count
3
2
3
62.5
age at onset
1
1
0
8.6
28.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
3
8.6
86.9
red blood cell distribution width
2
83.9
Myopia
0
4.8
78.7
reticulocyte count
3
62.5
age at onset
0
8.6
28.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 98
VGNC:9722
454577
Macaque
transmembrane protein 98
718166
Mouse
MGI:1923457
103743
Rat
RGD:1359736
303356
Dog
transmembrane protein 98
VGNC:47618
612961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 98
Macaque
transmembrane protein 98
Mouse
Rat
Dog
transmembrane protein 98
Publication Statistics
PubMed Score 15.22
PubMed score by year
PubTator Score 6.80
PubTator score by year
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Related Publications
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PMID
Year
Title