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Tchem
TMEM97
Sigma intracellular receptor 2

Protein Summary
Description
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588). TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226230
  • ENSP00000226230
  • ENSG00000109084

Symbol
  • MAC30
  • S2R
  • MAC30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
disease perturbation
0.98
histone modification site profile
0.88
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.14   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.14   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 157
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (18)
MADCAM1
Tbio
Novelty:  0.00325843
p_int:  0.999980867
p_ni:  0.000019129
p_wrong:  5e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
STXBP3
Tbio
Novelty:  0.03346737
p_int:  0.99665991
p_ni:  0.00334009
Score:  0.534
Data Source:  BioPlex,STRINGDB
GUK1
Tbio
Family:  Kinase
Novelty:  0.00475753
p_int:  0.993827229
p_ni:  0.006172771
Score:  0.535
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.991724365
p_ni:  0.008275611
p_wrong:  2.3e-8
Data Source:  BioPlex
TM2D2
Tdark
Novelty:  0.10390283
p_int:  0.967204739
p_ni:  0.032794853
p_wrong:  4.08e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.894223084
p_ni:  0.105776915
Score:  0.173
Data Source:  BioPlex,STRINGDB
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
p_int:  0.80477965
p_ni:  0.195220084
p_wrong:  2.65e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.80477965
p_ni:  0.195220084
p_wrong:  2.65e-7
Data Source:  BioPlex
NPC1
Tchem
Novelty:  0.00155015
Score:  0.946
Data Source:  STRINGDB
TMBIM4
Tbio
Novelty:  0.00736177
Score:  0.74
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
4
9
92.8
osteoprotegerin measurement
2
1
2
86.6
interleukin-27 measurement
1
1
1
84.6
apolipoprotein B measurement
2
3
3
83
apolipoprotein A 1 measurement
2
2
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
92.8
osteoprotegerin measurement
2
86.6
interleukin-27 measurement
1
84.6
apolipoprotein B measurement
3
83
apolipoprotein A 1 measurement
2
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 97
707879
Mouse
MGI:1916321
69071
Rat
RGD:1307423
303330
Dog
transmembrane protein 97
VGNC:47617
610900
Horse
transmembrane protein 97
VGNC:24327
100058915
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 97
Mouse
Rat
Dog
transmembrane protein 97
Horse
transmembrane protein 97
Publication Statistics
PubMed Score 180.14
PubMed score by year
PubTator Score 23.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title