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Tbio
TMEM9
Transmembrane protein 9

Protein Summary
Description
May be involved in intracellular transport.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367330
  • ENSP00000356299
  • ENSG00000116857
  • ENST00000367333
  • ENSP00000356302
  • ENST00000367334
  • ENSP00000356303
  • ENST00000485839
  • ENSP00000476893

Symbol
  • DERP4
  • TMEM9A
  • DERM4
  • TMEM9A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.8
histone modification site profile
0.78
cellular component
0.7
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.41   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.41   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
CLCN5
Tbio
Family:  IC
Novelty:  0.00419772
p_int:  0.999999995
p_ni:  5e-9
Score:  0.412
Data Source:  BioPlex,STRINGDB
CLCN3
Tchem
Family:  IC
Novelty:  0.00416196
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.412
Data Source:  BioPlex,STRINGDB
TMEM9B
Tdark
Novelty:  0.56628366
p_int:  0.999995479
p_ni:  8e-9
p_wrong:  0.000004513
Data Source:  BioPlex
OPA3
Tbio
Novelty:  0.01508376
p_int:  0.999986289
p_ni:  0.000012847
p_wrong:  8.64e-7
Data Source:  BioPlex
NEK6
Tchem
Family:  Kinase
Novelty:  0.02394134
p_int:  0.999792206
p_ni:  0.000168804
p_wrong:  0.00003899
Data Source:  BioPlex
HUS1
Tbio
Novelty:  0.00837493
p_int:  0.999660557
p_ni:  0.000339316
p_wrong:  1.27e-7
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.999513098
p_ni:  0.000486898
p_wrong:  4e-9
Data Source:  BioPlex
NDUFAF1
Tclin
Novelty:  0.05630549
p_int:  0.999419842
p_ni:  0.000580158
Data Source:  BioPlex
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.999010547
p_ni:  0.000989453
Data Source:  BioPlex
NDC1
Tbio
Novelty:  0.15840853
p_int:  0.998606141
p_ni:  0.001393064
p_wrong:  7.95e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
1
6
5.7
91.1
1
1
0
1.4
81.8
appendicular lean mass
2
1
2
73.3
creatinine measurement
2
1
2
61.2
lymphocyte count
3
1
3
60.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5.7
91.1
0
1.4
81.8
appendicular lean mass
2
73.3
creatinine measurement
2
61.2
lymphocyte count
3
60.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 9
708473
Mouse
MGI:1913491
66241
Rat
RGD:1307922
289046
Horse
transmembrane protein 9
VGNC:24324
100051835
Cow
transmembrane protein 9
VGNC:36125
100125921
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 9
Mouse
Rat
Horse
transmembrane protein 9
Cow
transmembrane protein 9
Publication Statistics
PubMed Score 17.41
PubMed score by year
PubTator Score 2.52
PubTator score by year
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Related Publications
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PMID
Year
Title