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Tdark
TMEM8A
Post-GPI attachment to proteins factor 6

Protein Summary
Description
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431232
  • ENSP00000401338
  • ENSG00000129925

Symbol
  • PGAP6
  • TMEM6
  • TMEM8
  • M83
  • PGAP6
  • TMEM6
  • TMEM8
  • GPI-PLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.88
histone modification site profile
0.76
transcription factor binding site profile
0.71
PubMedID
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
ATP1B4
Tdark
Family:  Transporter
Novelty:  0.08212894
p_int:  0.999944013
p_ni:  0.000055981
p_wrong:  6e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999838688
p_ni:  0.000075478
p_wrong:  0.000085834
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.999413191
p_ni:  0.000113393
p_wrong:  0.000473416
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.998990201
p_ni:  0.000993213
p_wrong:  0.000016586
Score:  0.247
Data Source:  BioPlex,STRINGDB
PCDHGC5
Tdark
Novelty:  0.39651826
p_int:  0.998937561
p_ni:  0.000153747
p_wrong:  0.000908692
Data Source:  BioPlex
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.998254955
p_ni:  0.001725271
p_wrong:  0.000019774
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.872718441
p_ni:  0.001908496
p_wrong:  0.125373063
Data Source:  BioPlex
ENHO
Tbio
Novelty:  0.01106852
Score:  0.719
Data Source:  STRINGDB
NPRL3
Tbio
Family:  Enzyme
Novelty:  0.0110744
Score:  0.707
Data Source:  STRINGDB
ACER1
Tbio
Family:  Enzyme
Novelty:  0.05571844
Score:  0.704
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
12
98.2
mean corpuscular hemoglobin concentration
4
5
6
97
platelet count
2
2
2
90.6
serum gamma-glutamyl transferase measurement
2
2
3
87.4
bone density
2
2
3
82.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
98.2
mean corpuscular hemoglobin concentration
6
97
platelet count
2
90.6
serum gamma-glutamyl transferase measurement
3
87.4
bone density
3
82.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 8A
VGNC:5942
453791
Macaque
transmembrane protein 8A
722297
Mouse
MGI:1926283
60455
Rat
RGD:1311395
303004
Dog
transmembrane protein 8A
VGNC:47614
479896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 8A
Macaque
transmembrane protein 8A
Mouse
Rat
Dog
transmembrane protein 8A
Publication Statistics
PubMed Score 6.74
PubMed score by year
PubTator Score 9.25
PubTator score by year
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Related Publications
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PMID
Year
Title