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Tbio
TMEM88
Transmembrane protein 88

Protein Summary
Description
Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301599
  • ENSP00000301599
  • ENSG00000167874

Symbol
  • TMEM88A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
virus perturbation
0.64
transcription factor
0.51
cellular component
0.43
tissue
0.39


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.26   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.26   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
DVL1
Tchem
Novelty:  0.00356876
Score:  0.748
Data Source:  STRINGDB
TMEM207
Tdark
Novelty:  0.35957705
Score:  0.715
Data Source:  STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.578
Data Source:  STRINGDB
DNAH2
Tbio
Novelty:  0.12847351
Score:  0.573
Data Source:  STRINGDB
GREB1L
Tdark
Novelty:  0.06421593
Score:  0.539
Data Source:  STRINGDB
SOWAHD
Tdark
Novelty:  6.91525424
Score:  0.531
Data Source:  STRINGDB
SLC25A48
Tdark
Family:  Transporter
Novelty:  1.08167819
Score:  0.524
Data Source:  STRINGDB
CDK10
Tchem
Family:  Kinase
Novelty:  0.02779968
Score:  0.514
Data Source:  STRINGDB
TNFAIP8L2
Tbio
Novelty:  0.01938521
Score:  0.501
Data Source:  STRINGDB
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
Score:  0.497
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
5
95.7
hematocrit
2
2
2
88.2
eosinophil count
3
1
3
85.7
hemoglobin measurement
3
2
3
84.2
neutrophil count
1
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.7
hematocrit
2
88.2
eosinophil count
3
85.7
hemoglobin measurement
3
84.2
neutrophil count
2
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 88
VGNC:9719
750636
Macaque
transmembrane protein 88
716381
Mouse
MGI:1914270
67020
Rat
RGD:1561781
497936
Dog
transmembrane protein 88
VGNC:47611
607946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 88
Macaque
transmembrane protein 88
Mouse
Rat
Dog
transmembrane protein 88
Publication Statistics
PubMed Score 15.26
PubMed score by year
PubTator Score 5.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title