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Tdark
TMEM87A
Transmembrane protein 87A

Protein Summary
Description
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307216
  • ENSP00000305894
  • ENSG00000103978
  • ENST00000389834
  • ENSP00000374484
  • ENST00000448392
  • ENSP00000405379
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
histone modification site profile
0.88
microRNA
0.79
transcription factor binding site profile
0.71
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.996894576
p_ni:  0.003105424
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.996454716
p_ni:  0.003545284
Data Source:  BioPlex
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.991195899
p_ni:  0.008804096
p_wrong:  5e-9
Score:  0.18
Data Source:  BioPlex,STRINGDB
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.991157573
p_ni:  0.008842425
p_wrong:  2e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.989647426
p_ni:  0.010352574
Data Source:  BioPlex
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.989351306
p_ni:  0.010646455
p_wrong:  0.000002239
Data Source:  BioPlex
ERAP1
Tchem
Family:  Enzyme
Novelty:  0.00404539
p_int:  0.988596582
p_ni:  0.011403187
p_wrong:  2.31e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.98834978
p_ni:  0.011650201
p_wrong:  1.8e-8
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.978814779
p_ni:  0.021067365
p_wrong:  0.000117857
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.972613139
p_ni:  0.027386861
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
1
2
82.1
basophil count
2
2
2
68.4
basophil percentage of leukocytes
1
1
1
59
fibrinogen measurement
2
2
2
51.4
granulocyte percentage of myeloid white cells
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
82.1
basophil count
2
68.4
basophil percentage of leukocytes
1
59
fibrinogen measurement
2
51.4
granulocyte percentage of myeloid white cells
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 87A
VGNC:1589
453359
Macaque
transmembrane protein 87A
100427665
Mouse
MGI:2441844
211499
Rat
RGD:1309417
366170
Horse
transmembrane protein 87A
VGNC:24320
100070982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 87A
Macaque
transmembrane protein 87A
Mouse
Rat
Horse
transmembrane protein 87A
Publication Statistics
PubMed Score 2.52
PubMed score by year
PubTator Score 1.25
PubTator score by year
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Related Publications
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PMID
Year
Title