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Tbio
TMEM70
Transmembrane protein 70, mitochondrial

Protein Summary
Description
Involved in biogenesis of mitochondrial ATP synthase. This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312184
  • ENSP00000312599
  • ENSG00000175606
  • ENST00000517439
  • ENSP00000429467

Symbol
  • MC5DN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.8
cellular component
0.75
virus perturbation
0.72
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.67   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.67   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ACSS1
Tbio
Family:  Enzyme
Novelty:  0.02003886
p_int:  0.999334761
p_ni:  0.000250995
p_wrong:  0.000414244
Score:  0.738
Data Source:  BioPlex,STRINGDB
CHDH
Tbio
Family:  Enzyme
Novelty:  0.02147468
p_int:  0.999150962
p_ni:  0.000821339
p_wrong:  0.000027698
Score:  0.189
Data Source:  BioPlex,STRINGDB
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.988581923
p_ni:  0.011418077
Data Source:  BioPlex
MIPEP
Tbio
Family:  Enzyme
Novelty:  0.01507033
p_int:  0.95747849
p_ni:  0.04252151
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.955244195
p_ni:  0.044755805
Score:  0.163
Data Source:  BioPlex,STRINGDB
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
p_int:  0.942978465
p_ni:  0.057020428
p_wrong:  0.000001107
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.925261835
p_ni:  0.074655193
p_wrong:  0.000082972
Data Source:  BioPlex
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.922338087
p_ni:  0.077661913
Data Source:  BioPlex
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
p_int:  0.91045749
p_ni:  0.08954251
Data Source:  BioPlex
COQ6
Tbio
Family:  Enzyme
Novelty:  0.0290336
p_int:  0.906978798
p_ni:  0.091756769
p_wrong:  0.001264433
Score:  0.271
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Nonalcoholic fatty liver disease
Name
Explore in Pharos
Explore in Source
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex I assembly model OXPHOS system
Nonalcoholic fatty liver disease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
47.7
alkaline phosphatase measurement
1
1
1
45.7
total cholesterol measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
47.7
alkaline phosphatase measurement
1
45.7
total cholesterol measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 70
VGNC:14602
464237
Macaque
transmembrane protein 70
696532
Mouse
MGI:1915068
70397
Rat
RGD:1566224
500384
Dog
transmembrane protein 70
VGNC:54122
477915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 70
Macaque
transmembrane protein 70
Mouse
Rat
Dog
transmembrane protein 70
Publication Statistics
PubMed Score 34.67
PubMed score by year
PubTator Score 27.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title