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Tbio
TMEM70
Transmembrane protein 70, mitochondrial

Protein Summary
Description
Involved in biogenesis of mitochondrial ATP synthase. This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312184
  • ENSP00000312599
  • ENSG00000175606
  • ENST00000517439
  • ENSP00000429467

Symbol
  • MC5DN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.8
cellular component
0.75
virus perturbation
0.72
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.7   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.7   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0