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Tdark
TMEM63C
Calcium permeable stress-gated cation channel 1

Protein Summary
Description
Acts as an osmosensitive calcium-permeable cation channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298351
  • ENSP00000298351
  • ENSG00000165548

Symbol
  • C14orf171
  • CSC1
  • CSC1
  • hsCSC1
  • C14orf171
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.69
gene perturbation
0.65
histone modification site profile
0.56
tissue sample
0.55
PubMedID
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
STX8
Tbio
Novelty:  0.01083752
p_int:  0.99998591
p_ni:  0.00001409
Data Source:  BioPlex
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
p_int:  0.999915076
p_ni:  0.000084924
Data Source:  BioPlex
ZNF787
Tdark
Family:  TF
Novelty:  0.11251187
p_int:  0.999910423
p_ni:  0.000005189
p_wrong:  0.000084387
Data Source:  BioPlex
RNFT1
Tdark
Novelty:  1.15288082
p_int:  0.999594271
p_ni:  0.000011152
p_wrong:  0.000394578
Data Source:  BioPlex
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.995371749
p_ni:  0.004602533
p_wrong:  0.000025718
Data Source:  BioPlex
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
p_int:  0.99302953
p_ni:  0.006970328
p_wrong:  1.43e-7
Data Source:  BioPlex
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.992116105
p_ni:  0.007661334
p_wrong:  0.000222561
Data Source:  BioPlex
OSBP
Tbio
Novelty:  0.00425747
p_int:  0.99170576
p_ni:  0.00829424
Data Source:  BioPlex
MINDY1
Tbio
Novelty:  0.31540765
p_int:  0.986497066
p_ni:  0.013218004
p_wrong:  0.00028493
Data Source:  BioPlex
DNAJC18
Tdark
Novelty:  1.38573997
p_int:  0.98607288
p_ni:  0.013926859
p_wrong:  2.62e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
58.4
mathematical ability
3
3
5
53.7
aspartate aminotransferase measurement
2
2
1
5.9
45.6
body mass index
1
1
1
42.3
C-reactive protein measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
58.4
mathematical ability
5
53.7
aspartate aminotransferase measurement
1
5.9
45.6
body mass index
1
42.3
C-reactive protein measurement
1
38.2
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 63C
VGNC:3300
453066
Mouse
MGI:2444386
217733
Rat
RGD:1310207
314332
Dog
transmembrane protein 63C
VGNC:47597
490804
Horse
transmembrane protein 63C
VGNC:24308
100052069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 63C
Mouse
Rat
Dog
transmembrane protein 63C
Horse
transmembrane protein 63C
Publication Statistics
PubMed Score 35.89
PubMed score by year
PubTator Score 38.93
PubTator score by year
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Related Publications
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PMID
Year
Title