Tdark TMEM63B CSC1-like protein 2

Protein Summary

Description

Acts as an osmosensitive calcium-permeable cation channel.

Uniprot Accession IDs

• Q5T3F8
• B9EGU3
• Q5T3F9
• Q6AHX4
• Q6P5A0
• Q8N219
• Q8NDE1
• Q9NSG5

Gene Name

• TMEM63B

Ensembl ID

• ENST00000259746
• ENSP00000259746
• ENSG00000137216
• ENST00000323267
• ENSP00000327154

Symbol

• C6orf110
• C6orf110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.71
transcription factor perturbation	0.61
histone modification site profile	0.6
cell type or tissue	0.58
transcription factor binding site profile	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.76   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.76   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0