Tdark TMEM63B CSC1-like protein 2

Protein Summary

Description

Acts as an osmosensitive calcium-permeable cation channel.

Uniprot Accession IDs

• Q5T3F8
• B9EGU3
• Q5T3F9
• Q6AHX4
• Q6P5A0
• Q8N219
• Q8NDE1
• Q9NSG5

Gene Name

• TMEM63B

Ensembl ID

• ENST00000259746
• ENSP00000259746
• ENSG00000137216
• ENST00000323267
• ENSP00000327154

Symbol

• C6orf110
• C6orf110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.71
transcription factor perturbation	0.61
histone modification site profile	0.6
cell type or tissue	0.58
transcription factor binding site profile	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

NKAIN1

Tdark

Family:  Enzyme

Novelty:  0.52190272

p_int:  0.999490649

p_ni:  0.00050935

p_wrong:  1e-9

Data Source:  BioPlex

SLC39A4

Tbio

Family:  Transporter

Novelty:  0.00742159

p_int:  0.998404596

p_ni:  0.001595326

p_wrong:  7.9e-8

Score:  0.154

Data Source:  BioPlex,STRINGDB

RXFP1

Tchem

Family:  GPCR

Novelty:  0.00580827

p_int:  0.996329925

p_ni:  0.003669216

p_wrong:  8.59e-7

Data Source:  BioPlex

PCDHA3

Tdark

Novelty:  0.8622898

p_int:  0.996288582

p_ni:  0.003711219

p_wrong:  2e-7

Data Source:  BioPlex

IL17RB

Tbio

Novelty:  0.01540031

p_int:  0.996219971

p_ni:  0.003779971

p_wrong:  5.9e-8

Data Source:  BioPlex

LRRC55

Tbio

Family:  IC

Novelty:  0.25121277

p_int:  0.995626525

p_ni:  0.004373288

p_wrong:  1.87e-7

Data Source:  BioPlex

MTUS2

Tbio

Novelty:  0.13504593

p_int:  0.994571762

p_ni:  0.005428234

p_wrong:  4e-9

Score:  0.159

Data Source:  BioPlex,STRINGDB

SLC22A2

Tchem

Family:  Transporter

Novelty:  0.00439263

p_int:  0.983313403

p_ni:  0.016413923

p_wrong:  0.000272673

Data Source:  BioPlex

SLC4A8

Tbio

Family:  Transporter

Novelty:  0.01606111

p_int:  0.983183334

p_ni:  0.016816638

p_wrong:  2.7e-8

Data Source:  BioPlex

ATP2B2

Tbio

Family:  Transporter

Novelty:  0.007782

p_int:  0.980637388

p_ni:  0.019362598

p_wrong:  1.4e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (3)

Find Similar Targets

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10

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GO Term	Evidence	Assigned by
calcium activated cation channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
erythrocyte count	EFO_0004305	2	2	2		89.2
hematocrit	EFO_0004348	5	1	5		87.3
hemoglobin measurement	EFO_0004509	4	1	4		87
red blood cell density measurement	EFO_0007978	2	1	2		86.7
mean reticulocyte volume	EFO_0010701	1	2	2		85

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
erythrocyte count	EFO_0004305	2		89.2
hematocrit	EFO_0004348	5		87.3
hemoglobin measurement	EFO_0004509	4		87
red blood cell density measurement	EFO_0007978	2		86.7
mean reticulocyte volume	EFO_0010701	2		85

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Complete proteome
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
erythrocyte count
heel bone mineral density
hematocrit
hemoglobin measurement
interleukin 12 measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume
mean reticulocyte volume
platelet crit

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
mortality/aging
vision/eye phenotype

IDG Resources

Reagents (1)

Data Resources (1)

Cell

IDG-HEK293T-TMEM63B-V5-OE

Details:

• RRID:  CVCL_YA83
• Species:  Homo sapiens

Data:

• IDG-HEK293T-TMEM63B-V5-OE

Order Cell from:

UCSF

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 63B	VGNC:3754	472016
Macaque	transmembrane protein 63B		702797
Mouse	transmembrane protein 63b	MGI:2387609	224807
Rat	transmembrane protein 63B	RGD:1305862	363197
Dog	transmembrane protein 63B	VGNC:47596	609620

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 63B
Macaque	transmembrane protein 63B
Mouse	transmembrane protein 63b
Rat	transmembrane protein 63B
Dog	transmembrane protein 63B

Publication Statistics

PubMed Score 4.23

PubMed score by year

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PubTator Score 0.33

PubTator score by year

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Related Publications

Text Mined References (5)

Items per page:

10

0 of 0

PMID	Year	Title