Protein Summary
Acts as an osmosensitive calcium-permeable cation channel.
- ENST00000259746
- ENSP00000259746
- ENSG00000137216
- ENST00000323267
- ENSP00000327154
- C6orf110
- C6orf110
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor | 0.71 | ||
transcription factor perturbation | 0.61 | ||
histone modification site profile | 0.6 | ||
cell type or tissue | 0.58 | ||
transcription factor binding site profile | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.23 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 34 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.23 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 34 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (68)
NKAIN1
Family: Enzyme
Novelty: 0.52190272
p_int: 0.999490649
p_ni: 0.00050935
p_wrong: 1e-9
Data Source: BioPlex
SLC39A4
Family: Transporter
Novelty: 0.00742159
p_int: 0.998404596
p_ni: 0.001595326
p_wrong: 7.9e-8
Score: 0.154
Data Source: BioPlex,STRINGDB
RXFP1
Family: GPCR
Novelty: 0.00580827
p_int: 0.996329925
p_ni: 0.003669216
p_wrong: 8.59e-7
Data Source: BioPlex
PCDHA3
Novelty: 0.8622898
p_int: 0.996288582
p_ni: 0.003711219
p_wrong: 2e-7
Data Source: BioPlex
IL17RB
Novelty: 0.01540031
p_int: 0.996219971
p_ni: 0.003779971
p_wrong: 5.9e-8
Data Source: BioPlex
LRRC55
Family: IC
Novelty: 0.25121277
p_int: 0.995626525
p_ni: 0.004373288
p_wrong: 1.87e-7
Data Source: BioPlex
MTUS2
Novelty: 0.13504593
p_int: 0.994571762
p_ni: 0.005428234
p_wrong: 4e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
SLC22A2
Family: Transporter
Novelty: 0.00439263
p_int: 0.983313403
p_ni: 0.016413923
p_wrong: 0.000272673
Data Source: BioPlex
SLC4A8
Family: Transporter
Novelty: 0.01606111
p_int: 0.983183334
p_ni: 0.016816638
p_wrong: 2.7e-8
Data Source: BioPlex
ATP2B2
Family: Transporter
Novelty: 0.007782
p_int: 0.980637388
p_ni: 0.019362598
p_wrong: 1.4e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
erythrocyte count | 2 | 2 | 2 | 89.2 | |||||
hematocrit | 5 | 1 | 5 | 87.3 | |||||
hemoglobin measurement | 4 | 1 | 4 | 87 | |||||
red blood cell density measurement | 2 | 1 | 2 | 86.7 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 85 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
erythrocyte count | 2 | 89.2 | |||||
hematocrit | 5 | 87.3 | |||||
hemoglobin measurement | 4 | 87 | |||||
red blood cell density measurement | 2 | 86.7 | |||||
mean reticulocyte volume | 2 | 85 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Data Resources (1)
Cell
IDG-HEK293T-TMEM63B-V5-OE

Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | transmembrane protein 63B | VGNC:3754 | 472016 | |||||
Macaque | transmembrane protein 63B | 702797 | ||||||
Mouse | MGI:2387609 | 224807 | ||||||
Rat | RGD:1305862 | 363197 | ||||||
Dog | transmembrane protein 63B | VGNC:47596 | 609620 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | transmembrane protein 63B | |||||
Macaque | transmembrane protein 63B | |||||
Mouse | ||||||
Rat | ||||||
Dog | transmembrane protein 63B | |||||
Publication Statistics
PubMed Score 4.23
PubMed score by year
PubTator Score 0.33
PubTator score by year
Related Publications
Text Mined References (5)
Items per page:
0 of 0
PMID | Year | Title |
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