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Tbio
TMEM59L
Transmembrane protein 59-like

Protein Summary
Description
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262817
  • ENSP00000262817
  • ENSG00000105696
  • ENST00000600490
  • ENSP00000470879

Symbol
  • BSMAP
  • C19orf4
  • BSMAP
  • C19orf4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.74
virus perturbation
0.68
cell type or tissue
0.59
histone modification site profile
0.54
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.43   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.43   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.999421563
p_ni:  0.000577702
p_wrong:  7.35e-7
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.999398756
p_ni:  0.000576239
p_wrong:  0.000025005
Data Source:  BioPlex
LRRC52
Tbio
Family:  IC
Novelty:  0.15407898
p_int:  0.998538822
p_ni:  0.00142073
p_wrong:  0.000040448
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.997778133
p_ni:  0.002221866
p_wrong:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.996733735
p_ni:  0.003089988
p_wrong:  0.000176276
Data Source:  BioPlex
ATP1B4
Tdark
Family:  Transporter
Novelty:  0.08212894
p_int:  0.996610207
p_ni:  0.003260645
p_wrong:  0.000129148
Score:  0.183
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.994694544
p_ni:  0.005302302
p_wrong:  0.000003153
Data Source:  BioPlex
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.991645211
p_ni:  0.007349734
p_wrong:  0.001005055
Data Source:  BioPlex
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.983951706
p_ni:  0.014791414
p_wrong:  0.00125688
Data Source:  BioPlex
MUC1
Tchem
Novelty:  0.00024203
p_int:  0.980141019
p_ni:  0.017778292
p_wrong:  0.002080688
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
4
86.8
Oral ulcer
1
1
0
1.1
73
blood metabolite measurement
1
1
1
60.2
visceral adipose tissue measurement
1
1
1
59.8
3
3
1
1.1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
86.8
Oral ulcer
0
1.1
73
blood metabolite measurement
1
60.2
visceral adipose tissue measurement
1
59.8
1
1.1
57.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 59 like
VGNC:3586
455863
Macaque
transmembrane protein 59 like
719572
Mouse
MGI:1915187
67937
Rat
RGD:1305557
306349
Dog
transmembrane protein 59 like
VGNC:47591
609259
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 59 like
Macaque
transmembrane protein 59 like
Mouse
Rat
Dog
transmembrane protein 59 like
Publication Statistics
PubMed Score 5.43
PubMed score by year
PubTator Score 8.20
PubTator score by year
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Related Publications
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PMID
Year
Title