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Tbio
TMEM59
Transmembrane protein 59

Protein Summary
Description
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234831
  • ENSP00000234831
  • ENSG00000116209

Symbol
  • C1orf8
  • DCF1
  • C1orf8
  • PRO195
  • UNQ169
  • HSPC001
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
histone modification site profile
0.87
transcription factor binding site profile
0.86
cellular component
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.72   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.72   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
IL20RB
Tbio
Novelty:  0.01747619
p_int:  0.760362705
p_ni:  0.239637295
Score:  0.54
Data Source:  BioPlex,STRINGDB
ATG16L1
Tbio
Novelty:  0.0031765
Score:  0.792
Data Source:  STRINGDB
TRAF3IP3
Tbio
Novelty:  0.12180834
Score:  0.776
Data Source:  STRINGDB
DEDD2
Tbio
Novelty:  0.2972826
Score:  0.745
Data Source:  STRINGDB
TINAGL1
Tbio
Novelty:  0.05578199
Score:  0.692
Data Source:  STRINGDB
CAVIN2
Tbio
Novelty:  0.00979388
Score:  0.634
Data Source:  STRINGDB
FAM120C
Tbio
Novelty:  0.03333181
Score:  0.626
Data Source:  STRINGDB
ATG101
Tbio
Novelty:  0.03407206
Score:  0.61
Data Source:  STRINGDB
RB1CC1
Tbio
Novelty:  0.00744817
Score:  0.582
Data Source:  STRINGDB
ATG13
Tbio
Novelty:  0.00951471
Score:  0.576
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 59
VGNC:1688
456871
Macaque
transmembrane protein 59
714942
Mouse
MGI:1929278
56374
Rat
RGD:1310313
100196907
Dog
transmembrane protein 59
VGNC:47590
479561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 59
Macaque
transmembrane protein 59
Mouse
Rat
Dog
transmembrane protein 59
Publication Statistics
PubMed Score 35.72
PubMed score by year
PubTator Score 12.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title