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Tdark
TMEM56
Transmembrane protein 56

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370203
  • ENSP00000359222
  • ENSG00000152078
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
gene perturbation
0.76
tissue sample
0.61
microRNA
0.59
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.999348742
p_ni:  0.000558995
p_wrong:  0.000092262
Data Source:  BioPlex
KDELR3
Tdark
Novelty:  0.33264767
p_int:  0.999213263
p_ni:  0.000539829
p_wrong:  0.000246908
Score:  0.359
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.998455321
p_ni:  0.001293303
p_wrong:  0.000251376
Data Source:  BioPlex
SLC7A14
Tbio
Family:  Transporter
Novelty:  0.1613451
p_int:  0.997928968
p_ni:  0.002002264
p_wrong:  0.000068768
Data Source:  BioPlex
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.995368129
p_ni:  0.004621062
p_wrong:  0.000010809
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.995209367
p_ni:  0.004782328
p_wrong:  0.000008305
Data Source:  BioPlex
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.975362151
p_ni:  0.002232711
p_wrong:  0.022405138
Score:  0.315
Data Source:  BioPlex,STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.970740388
p_ni:  0.01848383
p_wrong:  0.010775783
Data Source:  BioPlex
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.915915312
p_ni:  0.001870322
p_wrong:  0.082214366
Data Source:  BioPlex
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.91488559
p_ni:  0.003552726
p_wrong:  0.081561684
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
2
3
3
86.3
myeloid white cell count
1
1
1
5.7
alcohol consumption measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fatty acid measurement
3
86.3
myeloid white cell count
1
5.7
alcohol consumption measurement
1
1.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 56
VGNC:53209
469235
Macaque
transmembrane protein 56
709729
Mouse
MGI:1923195
99887
Rat
RGD:1563041
365924
Dog
transmembrane protein 56
490151
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 56
Macaque
transmembrane protein 56
Mouse
Rat
Dog
transmembrane protein 56
Publication Statistics
PubMed Score 1.08
PubMed score by year
PubTator Score 0.53
PubTator score by year
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Related Publications
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PMID
Year
Title