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Tdark
TMEM53
Transmembrane protein 53

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999576285
p_ni:  1.4e-8
p_wrong:  0.000423701
Data Source:  BioPlex
NME2P1
Tdark
Family:  Kinase
p_int:  0.945997598
p_ni:  0.0540024
p_wrong:  2e-9
Data Source:  BioPlex
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
Score:  0.778
Data Source:  STRINGDB
RNF220
Tbio
Family:  Enzyme
Novelty:  0.14024436
Score:  0.735
Data Source:  STRINGDB
ERI3
Tbio
Family:  Enzyme
Novelty:  0.08842487
Score:  0.729
Data Source:  STRINGDB
ACBD6
Tbio
Novelty:  0.3555227
Score:  0.725
Data Source:  STRINGDB
GORAB
Tbio
Novelty:  0.06288992
Score:  0.714
Data Source:  STRINGDB
NRBP2
Tbio
Family:  Kinase
Novelty:  0.28776838
Score:  0.704
Data Source:  STRINGDB
EPPK1
Tdark
Novelty:  0.03621061
Score:  0.667
Data Source:  STRINGDB
PUF60
Tbio
Novelty:  0.02667356
Score:  0.667
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
4
2
4
84.1
heart rate response to exercise
2
1
3
68.9
red blood cell distribution width
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
4
84.1
heart rate response to exercise
3
68.9
red blood cell distribution width
1
43.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 53
VGNC:1686
456513
Macaque
transmembrane protein 53
705023
Mouse
MGI:1916027
68777
Rat
RGD:1307066
313529
Dog
transmembrane protein 53
VGNC:47587
482522
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 53
Macaque
transmembrane protein 53
Mouse
Rat
Dog
transmembrane protein 53
Publication Statistics
PubMed Score 2.91
PubMed score by year
PubTator Score 1.20
PubTator score by year
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Related Publications
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PMID
Year
Title