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Tdark
TMEM52B
Transmembrane protein 52B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298530
  • ENSP00000298530
  • ENSG00000165685
  • ENST00000381923
  • ENSP00000371348

Symbol
  • C12orf59
  • C12orf59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
gene perturbation
0.65
microRNA
0.56
tissue sample
0.52
cell line
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.998570095
p_ni:  0.001429905
Data Source:  BioPlex
RHBDF2
Tbio
Family:  Enzyme
Novelty:  0.02487334
p_int:  0.997751183
p_ni:  0.000947251
p_wrong:  0.001301565
Score:  0.201
Data Source:  BioPlex,STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.995641453
p_ni:  0.004358547
Data Source:  BioPlex
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
p_int:  0.991942501
p_ni:  0.008053341
p_wrong:  0.000004159
Data Source:  BioPlex
PKP2
Tbio
Novelty:  0.00493803
p_int:  0.991410991
p_ni:  0.008589009
Data Source:  BioPlex
SLC26A2
Tbio
Family:  Transporter
Novelty:  0.00325201
p_int:  0.990246144
p_ni:  0.009753855
p_wrong:  1e-9
Data Source:  BioPlex
PHLDB3
Tdark
Novelty:  2.01921901
p_int:  0.989021308
p_ni:  0.010978692
Data Source:  BioPlex
MYADM
Tbio
Novelty:  0.11475375
p_int:  0.986046293
p_ni:  0.012535711
p_wrong:  0.001417995
Data Source:  BioPlex
ANKRD13D
Tdark
Novelty:  2.14380936
p_int:  0.983339181
p_ni:  0.016656741
p_wrong:  0.000004077
Score:  0.158
Data Source:  BioPlex,STRINGDB
MFAP3
Tdark
Novelty:  0.55512255
p_int:  0.965458103
p_ni:  0.034541897
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lectin-like oxidized LDL receptor 1 measurement
1
1
1
70.2
advanced glycosylation end product-specific receptor ligand measurement
1
1
1
26.6
self reported educational attainment
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lectin-like oxidized LDL receptor 1 measurement
1
70.2
advanced glycosylation end product-specific receptor ligand measurement
1
26.6
self reported educational attainment
1
2.8
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 52B
VGNC:5636
465286
Macaque
transmembrane protein 52B
722332
Mouse
MGI:2442838
330428
Rat
RGD:1586337
689963
Horse
transmembrane protein 52B
VGNC:24298
100062403
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 52B
Macaque
transmembrane protein 52B
Mouse
Rat
Horse
transmembrane protein 52B
Publication Statistics
PubMed Score 2.57
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title