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Tdark
TMEM51
Transmembrane protein 51

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376008
  • ENSP00000365176
  • ENSG00000171729
  • ENST00000376014
  • ENSP00000365182
  • ENST00000400796
  • ENSP00000383600
  • ENST00000428417
  • ENSP00000394899

Symbol
  • C1orf72
  • C1orf72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
gene perturbation
0.74
transcription factor binding site profile
0.72
transcription factor
0.65
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
FAM114A2
Tdark
Novelty:  0.40545319
p_int:  0.999987788
p_ni:  0.000012212
Score:  0.175
Data Source:  BioPlex,STRINGDB
PDCD4
Tchem
Novelty:  0.00213303
p_int:  0.999978597
p_ni:  0.000021397
p_wrong:  6e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999944392
p_ni:  0.000055608
Data Source:  BioPlex
RAB5IF
Tdark
Novelty:  0.66468447
p_int:  0.999874488
p_ni:  0.000088524
p_wrong:  0.000036988
Score:  0.213
Data Source:  BioPlex,STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.999824444
p_ni:  0.000175556
Data Source:  BioPlex
HSPA12A
Tbio
Novelty:  0.11999085
p_int:  0.999774355
p_ni:  0.000225644
p_wrong:  1e-9
Data Source:  BioPlex
PTER
Tbio
Family:  Enzyme
Novelty:  0.01347498
p_int:  0.99433841
p_ni:  0.005656611
p_wrong:  0.000004979
Score:  0.169
Data Source:  BioPlex,STRINGDB
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
p_int:  0.981949938
p_ni:  0.018050062
Data Source:  BioPlex
TTI1
Tbio
Novelty:  0.05516406
p_int:  0.978787708
p_ni:  0.021212291
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.971307801
p_ni:  0.028690395
p_wrong:  0.000001805
Score:  0.172
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
1
1
1
30.2
1
1
0
1.2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
1
30.2
0
1.2
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 51
VGNC:1684
739379
Macaque
transmembrane protein 51
693771
Mouse
MGI:2384874
214359
Rat
RGD:1565452
500578
Dog
transmembrane protein 51
VGNC:47586
607267
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 51
Macaque
transmembrane protein 51
Mouse
Rat
Dog
transmembrane protein 51
Publication Statistics
PubMed Score 1.55
PubMed score by year
PubTator Score 0.36
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title