Tbio TMEM47 Transmembrane protein 47

Protein Summary

Description

Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BQJ4
• Q5JR44

Gene Name

• TMEM47

Ensembl ID

• ENST00000275954
• ENSP00000275954
• ENSG00000147027

Symbol

• BCMP1
• TM4SF10
• BCMP1
• VAB-9
• TM4SF10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
kinase perturbation	0.84
PubMedID	0.78
small molecule perturbation	0.66
gene perturbation	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0