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Tbio
TMEM37
Voltage-dependent calcium channel gamma-like subunit

Protein Summary
Description
Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306406
  • ENSP00000303148
  • ENSG00000171227

Symbol
  • PR
  • PR
  • PR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
histone modification site profile
0.72
gene perturbation
0.71
molecular function
0.7
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 594.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 594.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
ASPRV1
Tbio
Family:  Enzyme
Novelty:  0.0278626
Score:  0.771
Data Source:  STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
Score:  0.763
Data Source:  STRINGDB
GLIPR2
Tbio
Novelty:  0.04546295
Score:  0.66
Data Source:  STRINGDB
SMPD4
Tbio
Family:  Enzyme
Novelty:  0.08266114
Score:  0.659
Data Source:  STRINGDB
JMJD1C
Tbio
Family:  Epigenetic
Novelty:  0.02919389
Score:  0.626
Data Source:  STRINGDB
GOSR1
Tbio
Novelty:  0.03139481
Score:  0.584
Data Source:  STRINGDB
RNF128
Tbio
Family:  Enzyme
Novelty:  0.10712495
Score:  0.581
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.569
Data Source:  STRINGDB
PSMA6
Tbio
Family:  Enzyme
Novelty:  0.01525994
Score:  0.553
Data Source:  STRINGDB
CRISP2
Tbio
Novelty:  0.01862113
Score:  0.545
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
1
1.1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
27.3
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 37
VGNC:14447
459575
Mouse
MGI:2157899
170706
Rat
RGD:628689
245953
Dog
transmembrane protein 37
VGNC:47573
610386
Cow
transmembrane protein 37
VGNC:36079
613815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 37
Mouse
Rat
Dog
transmembrane protein 37
Cow
transmembrane protein 37
Publication Statistics
PubMed Score 594.22
PubMed score by year
PubTator Score 325.13
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title