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Tbio
TMEM30B
Cell cycle control protein 50B

Protein Summary
Description
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000555868
  • ENSP00000450842
  • ENSG00000182107

Symbol
  • CDC50B
  • CDC50B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
transcription factor perturbation
0.8
virus perturbation
0.55
transcription factor binding site profile
0.54
microRNA
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
PCDH17
Tbio
Novelty:  0.03341603
p_int:  0.999999557
p_ni:  4.43e-7
Data Source:  BioPlex
PRTG
Tbio
Novelty:  0.05120525
p_int:  0.999999068
p_ni:  2.91e-7
p_wrong:  6.41e-7
Score:  0.535
Data Source:  BioPlex,STRINGDB
SGCE
Tbio
Novelty:  0.00449577
p_int:  0.999998772
p_ni:  7.84e-7
p_wrong:  4.44e-7
Data Source:  BioPlex
IGDCC4
Tbio
Novelty:  0.13243246
p_int:  0.999998079
p_ni:  1.29e-7
p_wrong:  0.000001792
Score:  0.177
Data Source:  BioPlex,STRINGDB
PCDHGA11
Tdark
Novelty:  0.44130091
p_int:  0.999995618
p_ni:  0.000004382
Data Source:  BioPlex
TYRO3
Tchem
Family:  Kinase
Novelty:  0.00233016
p_int:  0.999983894
p_ni:  0.000016032
p_wrong:  7.5e-8
Data Source:  BioPlex
P10314
Tbio
Novelty:  0.00270731
p_int:  0.999983788
p_ni:  0.000016212
Data Source:  BioPlex
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
p_int:  0.999983486
p_ni:  0.000016508
p_wrong:  6e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
TMEM230
Tbio
Novelty:  0.04459055
p_int:  0.999982631
p_ni:  0.000008771
p_wrong:  0.000008598
Score:  0.177
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999957747
p_ni:  0.000042253
Score:  0.162
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 30B
719590
Mouse
MGI:2442082
238257
Rat
RGD:1308732
314224
Cow
transmembrane protein 30B
VGNC:36075
539324
Anole lizard
transmembrane protein 30B [Source:HGNC Symbol;Acc:HGNC:27254]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 30B
Mouse
Rat
Cow
transmembrane protein 30B
Anole lizard
transmembrane protein 30B [Source:HGNC Symbol;Acc:HGNC:27254]
Publication Statistics
PubMed Score 2.57
PubMed score by year
PubTator Score 3.68
PubTator score by year
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Related Publications
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PMID
Year
Title