Protein Summary
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.
- ENST00000333175
- ENSP00000331423
- ENSG00000182087
- ENST00000356663
- ENSP00000349087
- C19orf6
- MBRL
- ASBABP1
- C19orf6
- R32184_3
- MEMBRALIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.69 | ||
cell line | 0.68 | ||
transcription factor perturbation | 0.61 | ||
transcription factor binding site profile | 0.6 | ||
cell type or tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.66 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.66 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (49)
TMUB2
Novelty: 1.76302035
p_int: 0.997564041
p_ni: 0.002435959
Score: 0.188
Data Source: BioPlex,STRINGDB
RNF185
Family: Enzyme
Novelty: 0.23911257
p_int: 0.98978283
p_ni: 0.01021717
Score: 0.188
Data Source: BioPlex,STRINGDB
YIPF3
Novelty: 0.12021667
p_int: 0.981527816
p_ni: 0.018472184
Score: 0.166
Data Source: BioPlex,STRINGDB
TMEM199
Novelty: 0.05799147
p_int: 0.979396689
p_ni: 0.020603311
Score: 0.179
Data Source: BioPlex,STRINGDB
APOC4
Novelty: 0.06304082
p_int: 0.955428517
p_ni: 0.044571482
p_wrong: 1e-9
Data Source: BioPlex
APOA2
Novelty: 0.00117627
p_int: 0.934521174
p_ni: 0.065478823
p_wrong: 3e-9
Data Source: BioPlex
B3GALT2
Family: Enzyme
Novelty: 0.23873109
p_int: 0.908442107
p_ni: 0.091557893
Score: 0.232
Data Source: BioPlex,STRINGDB
APOC2
Novelty: 0.0015496
p_int: 0.890113134
p_ni: 0.109886831
p_wrong: 3.5e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (6)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (41)
Items per page:
1 – 5 of 41
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 4 | 7 | 98.3 | |||||
lymphocyte count | 4 | 5 | 6 | 98.1 | |||||
reticulocyte count | 7 | 3 | 9 | 97.4 | |||||
mean platelet volume | 3 | 5 | 6 | 95.6 | |||||
red blood cell distribution width | 4 | 3 | 5 | 94.8 | |||||
Items per page:
1 – 5 of 41
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 7 | 98.3 | |||||
lymphocyte count | 6 | 98.1 | |||||
reticulocyte count | 9 | 97.4 | |||||
mean platelet volume | 6 | 95.6 | |||||
red blood cell distribution width | 5 | 94.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2177957 | 216157 | ||||||
Rat | RGD:1311136 | 299608 | ||||||
Dog | transmembrane protein 259 | VGNC:47561 | 476757 | |||||
Cow | transmembrane protein 259 | VGNC:36067 | 514413 | |||||
Pig | transmembrane protein 259 | 100622984 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | transmembrane protein 259 | |||||
Cow | transmembrane protein 259 | |||||
Pig | transmembrane protein 259 | |||||
Publication Statistics
PubMed Score 11.66
PubMed score by year
PubTator Score 13.53
PubTator score by year
Related Publications
Text Mined References (7)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
|---|