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Tbio
TMEM259
Membralin

Protein Summary
Description
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333175
  • ENSP00000331423
  • ENSG00000182087
  • ENST00000356663
  • ENSP00000349087

Symbol
  • C19orf6
  • MBRL
  • ASBABP1
  • C19orf6
  • R32184_3
  • MEMBRALIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
cell line
0.68
transcription factor perturbation
0.61
transcription factor binding site profile
0.6
cell type or tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.66   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.66   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
TMUB2
Tdark
Novelty:  1.76302035
p_int:  0.997564041
p_ni:  0.002435959
Score:  0.188
Data Source:  BioPlex,STRINGDB
RNF185
Tbio
Family:  Enzyme
Novelty:  0.23911257
p_int:  0.98978283
p_ni:  0.01021717
Score:  0.188
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.981527816
p_ni:  0.018472184
Score:  0.166
Data Source:  BioPlex,STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.979396689
p_ni:  0.020603311
Score:  0.179
Data Source:  BioPlex,STRINGDB
EMC6
Tbio
Novelty:  0.18299013
p_int:  0.97083461
p_ni:  0.02916539
Data Source:  BioPlex
APOC4
Tbio
Novelty:  0.06304082
p_int:  0.955428517
p_ni:  0.044571482
p_wrong:  1e-9
Data Source:  BioPlex
APOA2
Tbio
Novelty:  0.00117627
p_int:  0.934521174
p_ni:  0.065478823
p_wrong:  3e-9
Data Source:  BioPlex
B3GALT2
Tbio
Family:  Enzyme
Novelty:  0.23873109
p_int:  0.908442107
p_ni:  0.091557893
Score:  0.232
Data Source:  BioPlex,STRINGDB
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.891415934
p_ni:  0.108584066
Data Source:  BioPlex
APOC2
Tbio
Novelty:  0.0015496
p_int:  0.890113134
p_ni:  0.109886831
p_wrong:  3.5e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
4
7
98.3
lymphocyte count
4
5
6
98.1
reticulocyte count
7
3
9
97.4
mean platelet volume
3
5
6
95.6
red blood cell distribution width
4
3
5
94.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
7
98.3
lymphocyte count
6
98.1
reticulocyte count
9
97.4
mean platelet volume
6
95.6
red blood cell distribution width
5
94.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2177957
216157
Rat
RGD:1311136
299608
Dog
transmembrane protein 259
VGNC:47561
476757
Cow
transmembrane protein 259
VGNC:36067
514413
Pig
transmembrane protein 259
100622984
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 259
Cow
transmembrane protein 259
Pig
transmembrane protein 259
Publication Statistics
PubMed Score 11.66
PubMed score by year
PubTator Score 13.53
PubTator score by year
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Related Publications
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PMID
Year
Title