TMEM259
Membralin
Protein Summary
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.
- ENST00000333175
- ENSP00000331423
- ENSG00000182087
- ENST00000356663
- ENSP00000349087
- C19orf6
- MBRL
- ASBABP1
- C19orf6
- R32184_3
- MEMBRALIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.69 | ||
cell line | 0.68 | ||
transcription factor perturbation | 0.61 | ||
transcription factor binding site profile | 0.6 | ||
cell type or tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.55 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.55 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0