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Tdark
TMEM248
Transmembrane protein 248

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341567
  • ENSP00000340668
  • ENSG00000106609
  • ENST00000433271
  • ENSP00000405558

Symbol
  • C7orf42
  • C7orf42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.92
transcription factor perturbation
0.88
kinase perturbation
0.84
tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999998867
p_ni:  6.46e-7
p_wrong:  4.87e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
LCN12
Tdark
Novelty:  0.31492521
Score:  0.63
Data Source:  STRINGDB
ZNF469
Tbio
Family:  TF
Novelty:  0.03776751
Score:  0.626
Data Source:  STRINGDB
GLT8D2
Tbio
Family:  Enzyme
Novelty:  0.79488367
Score:  0.61
Data Source:  STRINGDB
IBTK
Tbio
Family:  Enzyme
Novelty:  0.03448246
Score:  0.593
Data Source:  STRINGDB
TENT5A
Tbio
Novelty:  0.08412895
Score:  0.572
Data Source:  STRINGDB
VKORC1L1
Tbio
Family:  Enzyme
Novelty:  0.11471737
Score:  0.561
Data Source:  STRINGDB
COL8A2
Tbio
Novelty:  0.01672103
Score:  0.555
Data Source:  STRINGDB
ARHGAP20
Tbio
Family:  Enzyme
Novelty:  0.16551888
Score:  0.553
Data Source:  STRINGDB
USP37
Tbio
Family:  Enzyme
Novelty:  0.05398974
Score:  0.546
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
3.2
57.8
corneal topography
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3.2
57.8
corneal topography
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 248
VGNC:14470
463454
Macaque
transmembrane protein 248
695654
Mouse
MGI:1918917
71667
Rat
RGD:1303319
288616
Dog
transmembrane protein 248
VGNC:47553
479707
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 248
Macaque
transmembrane protein 248
Mouse
Rat
Dog
transmembrane protein 248
Publication Statistics
PubMed Score 0.29
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title