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Tdark
TMEM245
Transmembrane protein 245

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374586
  • ENSP00000363714
  • ENSG00000106771

Symbol
  • C9orf5
  • CG2
  • CG-2
  • C9orf5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.95
transcription factor perturbation
0.94
transcription factor binding site profile
0.81
kinase perturbation
0.76
small molecule perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.3   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.3   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999988545
p_ni:  0.000011431
p_wrong:  2.4e-8
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.999977794
p_ni:  0.000022089
p_wrong:  1.17e-7
Data Source:  BioPlex
LYPD6
Tbio
Novelty:  0.13867181
p_int:  0.999967061
p_ni:  0.000032908
p_wrong:  3.1e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.998344649
p_ni:  0.00163789
p_wrong:  0.000017461
Data Source:  BioPlex
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.997829176
p_ni:  0.001899667
p_wrong:  0.000271158
Score:  0.16
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.996070639
p_ni:  0.003929359
p_wrong:  2e-9
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.995434796
p_ni:  0.004548918
p_wrong:  0.000016287
Data Source:  BioPlex
GPC1
Tbio
Novelty:  0.00293087
p_int:  0.97341259
p_ni:  0.026418663
p_wrong:  0.000168747
Score:  0.161
Data Source:  BioPlex,STRINGDB
BTN3A2
Tbio
Novelty:  0.06889505
p_int:  0.961124633
p_ni:  0.005062339
p_wrong:  0.033813027
Score:  0.239
Data Source:  BioPlex,STRINGDB
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.897990142
p_ni:  0.00316085
p_wrong:  0.098849009
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
3
3
86.3
glucose measurement
2
2
2
78.2
waist-hip ratio
3
2
3
75.7
mathematical ability
3
3
3
72.6
fasting blood glucose measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
86.3
glucose measurement
2
78.2
waist-hip ratio
3
75.7
mathematical ability
3
72.6
fasting blood glucose measurement
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 245
VGNC:4881
464645
Macaque
transmembrane protein 245
710299
Mouse
MGI:2445107
242474
Rat
RGD:1308958
298020
Dog
transmembrane protein 245
VGNC:47551
403527
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 245
Macaque
transmembrane protein 245
Mouse
Rat
Dog
transmembrane protein 245
Publication Statistics
PubMed Score 3.30
PubMed score by year
PubTator Score 77.87
PubTator score by year
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Related Publications
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PMID
Year
Title