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Tbio
TMEM230
Transmembrane protein 230

Protein Summary
Description
Involved in trafficking and recycling of synaptic vesicles. This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000202834
  • ENSP00000202834
  • ENSG00000089063
  • ENST00000342308
  • ENSP00000341364
  • ENST00000379277
  • ENSP00000368579
  • ENST00000379279
  • ENSP00000368581
  • ENST00000379283
  • ENSP00000368585
  • ENST00000379286
  • ENSP00000368588
  • ENST00000379299
  • ENSP00000368601

Symbol
  • C20orf30
  • HSPC274
  • C20orf30
  • dJ1116H23.2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.94
transcription factor binding site profile
0.84
histone modification site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.04   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.04   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.999996771
p_ni:  0.000003207
p_wrong:  2.2e-8
Score:  0.216
Data Source:  BioPlex,STRINGDB
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999982631
p_ni:  0.000008771
p_wrong:  0.000008598
Score:  0.177
Data Source:  BioPlex,STRINGDB
C9orf78
Tdark
Novelty:  0.63248782
Score:  0.747
Data Source:  STRINGDB
LRRK2
Tchem
Family:  Kinase
Novelty:  0.00068078
Score:  0.586
Data Source:  STRINGDB
VPS13C
Tbio
Novelty:  0.05207291
Score:  0.577
Data Source:  STRINGDB
MECR
Tbio
Family:  Enzyme
Novelty:  0.01395965
Score:  0.569
Data Source:  STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
Score:  0.56
Data Source:  STRINGDB
VPS35
Tbio
Novelty:  0.00729892
Score:  0.558
Data Source:  STRINGDB
ZNF575
Tdark
Family:  TF
Novelty:  2.85540608
Score:  0.557
Data Source:  STRINGDB
STX1B
Tbio
Novelty:  0.01171833
Score:  0.54
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
75.4
mean corpuscular hemoglobin concentration
1
1
1
71.5
viral load
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
75.4
mean corpuscular hemoglobin concentration
1
71.5
viral load
1
66.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 230
VGNC:14140
458080
Macaque
transmembrane protein 230
717987
Mouse
MGI:1917862
70612
Rat
RGD:1307399
681315
Dog
transmembrane protein 230
VGNC:47541
477167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 230
Macaque
transmembrane protein 230
Mouse
Rat
Dog
transmembrane protein 230
Publication Statistics
PubMed Score 26.04
PubMed score by year
PubTator Score 19.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title