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Tdark
TMEM223
Transmembrane protein 223

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.998982064
p_ni:  0.00101689
p_wrong:  0.000001046
Data Source:  BioPlex
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.991127569
p_ni:  0.008872431
Data Source:  BioPlex
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.98233802
p_ni:  0.01766198
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.98063813
p_ni:  0.019359361
p_wrong:  0.000002509
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.980297665
p_ni:  0.019693343
p_wrong:  0.000008992
Data Source:  BioPlex
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
p_int:  0.975978993
p_ni:  0.024009392
p_wrong:  0.000011615
Data Source:  BioPlex
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
p_int:  0.973438195
p_ni:  0.026542039
p_wrong:  0.000019766
Data Source:  BioPlex
TTMP
Tdark
Novelty:  0.22491726
p_int:  0.968793011
p_ni:  0.00246973
p_wrong:  0.028737258
Data Source:  BioPlex
PCDHA4
Tdark
Novelty:  0.30511211
p_int:  0.966735858
p_ni:  0.03326414
p_wrong:  2e-9
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.96604073
p_ni:  0.033937779
p_wrong:  0.000021491
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
2
2
40.4
waist-hip ratio
1
2
2
38.7
smoking status measurement
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
40.4
waist-hip ratio
2
38.7
smoking status measurement
1
26.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 223
VGNC:972
451266
Macaque
transmembrane protein 223
722231
Dog
transmembrane protein 223
VGNC:47537
612187
Horse
transmembrane protein 223
VGNC:24262
100063983
Cow
transmembrane protein 223
VGNC:36044
616632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 223
Macaque
transmembrane protein 223
Dog
transmembrane protein 223
Horse
transmembrane protein 223
Cow
transmembrane protein 223
Publication Statistics
PubMed Score 0.90
PubMed score by year
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Related Publications
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PMID
Year
Title