You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TMEM218
Transmembrane protein 218

Protein Summary
Description
May be involved in ciliary biogenesis or function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279968
  • ENSP00000279968
  • ENSG00000150433
  • ENST00000526175
  • ENSP00000436177
  • ENST00000527271
  • ENSP00000436162
  • ENST00000527766
  • ENSP00000435526
  • ENST00000529583
  • ENSP00000433374
  • ENST00000531909
  • ENSP00000436596
  • ENST00000532407
  • ENSP00000434597
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
tissue sample
0.64
microRNA
0.6
transcription factor perturbation
0.54
cell type or tissue
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.975369197
p_ni:  0.010987686
p_wrong:  0.013643117
Score:  0.474
Data Source:  BioPlex,STRINGDB
CDKL1
Tchem
Family:  Kinase
Novelty:  0.110338
Score:  0.771
Data Source:  STRINGDB
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
Score:  0.667
Data Source:  STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
Score:  0.597
Data Source:  STRINGDB
B9D1
Tbio
Novelty:  0.11567839
Score:  0.58
Data Source:  STRINGDB
TMEM107
Tbio
Novelty:  0.02571599
Score:  0.567
Data Source:  STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
Score:  0.563
Data Source:  STRINGDB
TMEM237
Tdark
Novelty:  0.27005874
Score:  0.555
Data Source:  STRINGDB
KIF9
Tbio
Novelty:  0.12089339
Score:  0.551
Data Source:  STRINGDB
CEP89
Tbio
Novelty:  0.17461805
Score:  0.549
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
86
testosterone measurement
4
1
4
70.5
1
1
0
1.1
54.4
1
1
0
1.3
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
86
testosterone measurement
4
70.5
0
1.1
54.4
0
1.3
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 218
VGNC:973
451644
Mouse
MGI:1913529
66279
Rat
RGD:1311364
300516
Dog
transmembrane protein 218
VGNC:47534
479400
Horse
transmembrane protein 218
VGNC:24259
100064265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 218
Mouse
Rat
Dog
transmembrane protein 218
Horse
transmembrane protein 218
Publication Statistics
PubMed Score 2.24
PubMed score by year
PubTator Score 1.10
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title