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Tdark
TMEM214
Transmembrane protein 214

Protein Summary
Description
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238788
  • ENSP00000238788
  • ENSG00000119777
  • ENST00000321326
  • ENSP00000319469
  • ENST00000404032
  • ENSP00000384417
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
interacting protein
0.81
disease perturbation
0.74
transcription factor perturbation
0.74
cellular component
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.93   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.999969248
p_ni:  0.000030752
Data Source:  BioPlex
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.999952287
p_ni:  0.000047713
Data Source:  BioPlex
RPRM
Tbio
Novelty:  0.02938708
p_int:  0.99932491
p_ni:  0.00067509
Data Source:  BioPlex
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
p_int:  0.999127301
p_ni:  0.000872699
Score:  0.222
Data Source:  BioPlex,STRINGDB
SEMA7A
Tbio
Novelty:  0.00741605
p_int:  0.998795086
p_ni:  0.001204913
p_wrong:  1e-9
Data Source:  BioPlex
CSGALNACT1
Tbio
Family:  Enzyme
Novelty:  0.03463325
p_int:  0.998500532
p_ni:  0.001499468
Score:  0.248
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.998076314
p_ni:  0.001923686
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.998036503
p_ni:  0.001963497
Data Source:  BioPlex
KIR3DL2
Tbio
Novelty:  0.00321353
p_int:  0.997914618
p_ni:  0.002085379
p_wrong:  3e-9
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.997664352
p_ni:  0.002335648
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
5
5
82.3
brain measurement
1
1
0
20.6
77.2
cortical thickness
1
1
0
15.3
75
neutrophil count
1
1
1
63.2
neutrophil percentage of leukocytes
1
1
1
59.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
82.3
brain measurement
0
20.6
77.2
cortical thickness
0
15.3
75
neutrophil count
1
63.2
neutrophil percentage of leukocytes
1
59.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 214
VGNC:10792
459090
Macaque
transmembrane protein 214
699775
Mouse
MGI:1916046
68796
Rat
RGD:1311324
362711
Dog
transmembrane protein 214
VGNC:47532
610996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 214
Macaque
transmembrane protein 214
Mouse
Rat
Dog
transmembrane protein 214
Publication Statistics
PubMed Score 4.93
PubMed score by year
PubTator Score 0.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title