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Tdark
TMEM208
Transmembrane protein 208

Protein Summary
Description
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy. This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304800
  • ENSP00000305892
  • ENSG00000168701
  • ENST00000562235
  • ENSP00000457502

Symbol
  • HSPC171
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.82
virus perturbation
0.76
transcription factor perturbation
0.74
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
DUSP12
Tbio
Family:  Enzyme
Novelty:  0.00865145
p_int:  0.999999358
p_ni:  5.44e-7
p_wrong:  9.8e-8
Data Source:  BioPlex
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.99995144
p_ni:  0.000005721
p_wrong:  0.000042839
Score:  0.833
Data Source:  BioPlex,STRINGDB
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.999337469
p_ni:  0.000662529
p_wrong:  2e-9
Data Source:  BioPlex
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.996839861
p_ni:  0.00316011
p_wrong:  2.8e-8
Data Source:  BioPlex
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.996610197
p_ni:  0.003389417
p_wrong:  3.86e-7
Data Source:  BioPlex
RABAC1
Tbio
Novelty:  0.01749453
p_int:  0.996208416
p_ni:  0.003736893
p_wrong:  0.000054691
Data Source:  BioPlex
RDH13
Tbio
Family:  Enzyme
Novelty:  0.20184998
p_int:  0.996106589
p_ni:  0.003893411
Data Source:  BioPlex
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.993029646
p_ni:  0.000130039
p_wrong:  0.006840315
Score:  0.719
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.978990221
p_ni:  0.000196803
p_wrong:  0.020812976
Score:  0.193
Data Source:  BioPlex,STRINGDB
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.963128928
p_ni:  0.000078712
p_wrong:  0.03679236
Score:  0.542
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
4
4
96.2
mean reticulocyte volume
1
4
4
94.2
heel bone mineral density
3
3
6
93.1
BMI-adjusted waist circumference
4
4
7
64.4
high density lipoprotein cholesterol measurement
2
2
2
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
96.2
mean reticulocyte volume
4
94.2
heel bone mineral density
6
93.1
BMI-adjusted waist circumference
7
64.4
high density lipoprotein cholesterol measurement
2
62.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 208
VGNC:5940
741573
Macaque
transmembrane protein 208
697228
Mouse
MGI:1913570
66320
Rat
RGD:1560953
291963
Dog
transmembrane protein 208
VGNC:47527
489761
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 208
Macaque
transmembrane protein 208
Mouse
Rat
Dog
transmembrane protein 208
Publication Statistics
PubMed Score 2.13
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
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PMID
Year
Title