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Tdark
TMEM206
Transmembrane protein 206

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261455
  • ENSP00000261455
  • ENSG00000065600
  • ENST00000535273
  • ENSP00000438863

Symbol
  • C1orf75
  • C1orf75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
kinase perturbation
0.84
histone modification site profile
0.8
tissue sample
0.67
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
TMEM147
Tbio
Novelty:  0.39056101
p_int:  0.999998412
p_ni:  0.000001525
p_wrong:  6.2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
NOP9
Tdark
Novelty:  2.89535198
p_int:  0.999948695
p_ni:  0.000051304
p_wrong:  1e-9
Data Source:  BioPlex
DCUN1D5
Tchem
Novelty:  0.56719852
p_int:  0.999935065
p_ni:  0.000052423
p_wrong:  0.000012512
Data Source:  BioPlex
KNTC1
Tbio
Novelty:  0.08083785
p_int:  0.999816781
p_ni:  0.000183219
Data Source:  BioPlex
WDR3
Tbio
Novelty:  0.15410886
p_int:  0.999639804
p_ni:  0.000360196
Data Source:  BioPlex
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
p_int:  0.999548841
p_ni:  0.000451159
Data Source:  BioPlex
THADA
Tbio
Novelty:  0.06983966
p_int:  0.999518696
p_ni:  0.000481304
Data Source:  BioPlex
ZWILCH
Tbio
Novelty:  0.05184569
p_int:  0.999389086
p_ni:  0.000610914
Data Source:  BioPlex
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.999363506
p_ni:  0.000636493
p_wrong:  1e-9
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999346796
p_ni:  0.000653204
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
4
5
95.3
basophil percentage of leukocytes
1
2
2
79.5
monocyte count
1
1
1
78.9
BMI-adjusted waist circumference
1
2
2
60.8
BMI-adjusted waist-hip ratio
2
3
3
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
5
95.3
basophil percentage of leukocytes
2
79.5
monocyte count
1
78.9
BMI-adjusted waist circumference
2
60.8
BMI-adjusted waist-hip ratio
3
51.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 206
VGNC:10928
457717
Mouse
MGI:1914200
66950
Rat
RGD:1359339
305070
Dog
transmembrane protein 206
VGNC:47525
612794
Horse
transmembrane protein 206
VGNC:24249
100050924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 206
Mouse
Rat
Dog
transmembrane protein 206
Horse
transmembrane protein 206
Publication Statistics
PubMed Score 6.27
PubMed score by year
PubTator Score 0.14
PubTator score by year
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Related Publications
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PMID
Year
Title