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Tdark
TMEM205
Transmembrane protein 205

Protein Summary
Description
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354882
  • ENSP00000346954
  • ENSG00000105518
  • ENST00000447337
  • ENSP00000398258
  • ENST00000586590
  • ENSP00000466986
  • ENST00000586956
  • ENSP00000465483
  • ENST00000587948
  • ENSP00000465149
  • ENST00000588560
  • ENSP00000466495
  • ENST00000589555
  • ENSP00000465553
  • ENST00000593256
  • ENSP00000468733

Symbol
  • UNQ501
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
histone modification site profile
0.77
gene perturbation
0.74
small molecule perturbation
0.68
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.99999401
p_ni:  0.000005989
p_wrong:  1e-9
Data Source:  BioPlex
RBP4
Tchem
Novelty:  0.00168442
p_int:  0.993232862
p_ni:  0.00518319
p_wrong:  0.001583948
Score:  0.187
Data Source:  BioPlex,STRINGDB
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.986078834
p_ni:  0.013509359
p_wrong:  0.000411806
Data Source:  BioPlex
TMEM52B
Tdark
Novelty:  1.55824039
p_int:  0.946380294
p_ni:  0.053619475
p_wrong:  2.31e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
ECSCR
Tbio
Novelty:  0.11603718
p_int:  0.924554588
p_ni:  0.075440196
p_wrong:  0.000005216
Data Source:  BioPlex
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
p_int:  0.917458388
p_ni:  0.082538045
p_wrong:  0.000003568
Data Source:  BioPlex
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.868072761
p_ni:  0.13158673
p_wrong:  0.000340508
Data Source:  BioPlex
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.823239905
p_ni:  0.176760094
Score:  0.183
Data Source:  BioPlex,STRINGDB
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
p_int:  0.761899282
p_ni:  0.238096848
p_wrong:  0.000003869
Score:  0.158
Data Source:  BioPlex,STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.755260374
p_ni:  0.2440147
p_wrong:  0.000724927
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
2
2
80.2
diastolic blood pressure
1
1
1
78.6
Agents acting on the renin-angiotensin system use measurement
1
1
1
76.5
3
1
1
7.8
65.4
Calcium channel blocker use measurement
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
80.2
diastolic blood pressure
1
78.6
Agents acting on the renin-angiotensin system use measurement
1
76.5
1
7.8
65.4
Calcium channel blocker use measurement
1
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 205
VGNC:2222
100610018
Mouse
MGI:3045495
235043
Rat
RGD:1563250
300441
Dog
transmembrane protein 205
VGNC:47524
476707
Horse
transmembrane protein 205
VGNC:24248
100057187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 205
Mouse
Rat
Dog
transmembrane protein 205
Horse
transmembrane protein 205
Publication Statistics
PubMed Score 3.68
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
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PMID
Year
Title