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Tdark
TMEM204
Transmembrane protein 204

Protein Summary
Description
Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens. C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253934
  • ENSP00000253934
  • ENSG00000131634
  • ENST00000566264
  • ENSP00000454945

Symbol
  • C16orf30
  • CLP24
  • CLP24
  • C16orf30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
cell line
0.68
tissue sample
0.54
PubMedID
0.5
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
KLHDC8B
Tbio
Novelty:  0.15409379
Score:  0.746
Data Source:  STRINGDB
KBTBD12
Tdark
Novelty:  3.42794501
Score:  0.746
Data Source:  STRINGDB
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
Score:  0.742
Data Source:  STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
Score:  0.736
Data Source:  STRINGDB
CCDC36
Tbio
Novelty:  0.17724141
Score:  0.709
Data Source:  STRINGDB
KCNG3
Tclin
Family:  IC
Novelty:  0.19740057
Score:  0.706
Data Source:  STRINGDB
DECR2
Tbio
Family:  Enzyme
Novelty:  0.03928974
Score:  0.701
Data Source:  STRINGDB
RAB11FIP3
Tbio
Novelty:  0.07915085
Score:  0.665
Data Source:  STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
Score:  0.654
Data Source:  STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
Score:  0.652
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
2
2
74.7
heel bone mineral density
2
2
2
58.9
femoral neck bone mineral density
1
1
1
24.3
1
1
0
1.2
21.5
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
2
74.7
heel bone mineral density
2
58.9
femoral neck bone mineral density
1
24.3
0
1.2
21.5
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 204
VGNC:13801
104002483
Mouse
MGI:3039635
407831
Rat
RGD:1359314
287129
Dog
transmembrane protein 204
VGNC:47523
100686333
Horse
transmembrane protein 204
VGNC:24247
100065461
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 204
Mouse
Rat
Dog
transmembrane protein 204
Horse
transmembrane protein 204
Publication Statistics
PubMed Score 4.85
PubMed score by year
PubTator Score 1.63
PubTator score by year
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Related Publications
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PMID
Year
Title