Tbio TMEM201 Transmembrane protein 201

Protein Summary

Description

Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). Isoform 2: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090).

Uniprot Accession IDs

• Q5SNT2
• B9EH90
• Q5SNT3

Gene Name

• TMEM201

Ensembl ID

• ENST00000340305
• ENSP00000344772
• ENSG00000188807
• ENST00000340381
• ENSP00000344503

Symbol

• NET5
• SAMP1
• Ima1
• NET5
• SAMP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.75
transcription factor	0.74
transcription factor perturbation	0.74
tissue sample	0.72
transcription factor binding site profile	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.65   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 19   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.65   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0