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Tbio
TMEM199
Transmembrane protein 199

Protein Summary
Description
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833330). The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) in some human cells. The encoded protein shares some homology with the yeast protein Vma12. Defects in this gene are a cause of congenital disorder of glycosylation, type IIp. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292114
  • ENSP00000292114
  • ENSG00000244045

Symbol
  • C17orf32
  • VPH2
  • CDG2P
  • VMA12
  • C17orf32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.88
transcription factor perturbation
0.8
disease perturbation
0.74
transcription factor binding site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.06   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.06   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.999999997
p_ni:  3e-9
Score:  0.958
Data Source:  BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty:  0.00357665
p_int:  0.999996004
p_ni:  0.000003996
Score:  0.927
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999984702
p_ni:  0.000015298
Score:  0.992
Data Source:  BioPlex,STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.999959484
p_ni:  0.000040373
p_wrong:  1.43e-7
Data Source:  BioPlex
KIAA2013
Tdark
Novelty:  0.4705158
p_int:  0.999939639
p_ni:  0.000060361
Score:  0.855
Data Source:  BioPlex,STRINGDB
ATP6V0D2
Tbio
Family:  Enzyme
Novelty:  0.0354396
p_int:  0.999928234
p_ni:  0.000071766
Score:  0.994
Data Source:  BioPlex,STRINGDB
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
p_int:  0.999893716
p_ni:  0.000103901
p_wrong:  0.000002383
Score:  0.935
Data Source:  BioPlex,STRINGDB
TSPAN17
Tdark
Novelty:  0.51639684
p_int:  0.999560054
p_ni:  0.000439944
p_wrong:  1e-9
Data Source:  BioPlex
ATP6V0E1
Tbio
Family:  Enzyme
Novelty:  0.076209
p_int:  0.998352683
p_ni:  0.001545249
p_wrong:  0.000102068
Score:  0.872
Data Source:  BioPlex,STRINGDB
MUC1
Tchem
Novelty:  0.00024203
p_int:  0.997257064
p_ni:  0.002742936
p_wrong:  1e-9
Score:  0.725
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
GOC
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
4
9
92.8
osteoprotegerin measurement
2
1
2
86.6
interleukin-27 measurement
1
1
1
84.6
apolipoprotein B measurement
2
3
3
83
apolipoprotein A 1 measurement
2
2
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
92.8
osteoprotegerin measurement
2
86.6
interleukin-27 measurement
1
84.6
apolipoprotein B measurement
3
83
apolipoprotein A 1 measurement
2
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 199
VGNC:9718
454526
Macaque
transmembrane protein 199
708298
Mouse
MGI:2144113
195040
Rat
RGD:1566425
303332
Dog
transmembrane protein 199
VGNC:47517
491163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 199
Macaque
transmembrane protein 199
Mouse
Rat
Dog
transmembrane protein 199
Publication Statistics
PubMed Score 20.06
PubMed score by year
PubTator Score 5.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title