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Tdark
TMEM186
Transmembrane protein 186

Protein Summary
Description
This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333050
  • ENSP00000331640
  • ENSG00000184857

Symbol
  • C16orf51
  • C16orf51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.72
kinase perturbation
0.71
virus perturbation
0.64
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.999885931
p_ni:  0.000114069
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999426774
p_ni:  0.000573222
p_wrong:  4e-9
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.998720053
p_ni:  0.001279946
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.998473114
p_ni:  0.001526505
p_wrong:  3.81e-7
Data Source:  BioPlex
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.997464924
p_ni:  0.002535072
p_wrong:  4e-9
Data Source:  BioPlex
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.997215509
p_ni:  0.002784474
p_wrong:  1.7e-8
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.995069463
p_ni:  0.004930378
p_wrong:  1.59e-7
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.992612678
p_ni:  0.00738716
p_wrong:  1.63e-7
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.988791664
p_ni:  0.011208336
Data Source:  BioPlex
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.987449247
p_ni:  0.009491701
p_wrong:  0.003059053
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to opioid
1
1
1
21.5
chronotype measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to opioid
1
21.5
chronotype measurement
1
15.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 186
VGNC:5939
453904
Macaque
transmembrane protein 186
714067
Mouse
MGI:1913940
66690
Rat
RGD:1561167
497863
Horse
transmembrane protein 186
VGNC:24236
100057560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 186
Macaque
transmembrane protein 186
Mouse
Rat
Horse
transmembrane protein 186
Publication Statistics
PubMed Score 1.12
PubMed score by year
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Related Publications
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PMID
Year
Title