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Tdark
TMEM185A
Transmembrane protein 185A

Protein Summary
Description
The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000600449
  • ENSP00000471932
  • ENSG00000269556

Symbol
  • CXorf13
  • FAM11A
  • ee3
  • FRAXF
  • FAM11A
  • CXorf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.87
disease perturbation
0.68
tissue sample
0.6
histone modification site profile
0.59
transcription factor
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.29   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.29   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
TMEM185B
Tdark
Novelty:  0.90492561
p_int:  0.99999725
p_ni:  1e-9
p_wrong:  0.000002749
Score:  0.225
Data Source:  BioPlex,STRINGDB
AIDA
Tbio
Novelty:  0.7243992
p_int:  0.999941113
p_ni:  0.000045657
p_wrong:  0.00001323
Data Source:  BioPlex
TBC1D24
Tbio
Novelty:  0.0161631
p_int:  0.999914735
p_ni:  0.000085263
p_wrong:  1e-9
Data Source:  BioPlex
CCNY
Tbio
Novelty:  0.01400663
p_int:  0.999885158
p_ni:  0.000114818
p_wrong:  2.4e-8
Data Source:  BioPlex
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.999743191
p_ni:  0.000256808
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.999569861
p_ni:  0.000430139
Score:  0.254
Data Source:  BioPlex,STRINGDB
GNAZ
Tbio
Novelty:  0.02008523
p_int:  0.997985985
p_ni:  0.002014013
p_wrong:  3e-9
Data Source:  BioPlex
EEPD1
Tbio
Family:  Enzyme
Novelty:  0.28148309
p_int:  0.997254889
p_ni:  0.002745097
p_wrong:  1.4e-8
Data Source:  BioPlex
CSNK1G1
Tchem
Family:  Kinase
Novelty:  0.10919141
p_int:  0.997012687
p_ni:  0.002981407
p_wrong:  0.000005906
Score:  0.548
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.996915922
p_ni:  0.003084075
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 185A
705538
Mouse
MGI:2448555
236848
Rat
RGD:1563037
309357
Dog
transmembrane protein 185A
VGNC:47511
481072
Horse
transmembrane protein 185A
VGNC:24235
100069905
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 185A
Mouse
Rat
Dog
transmembrane protein 185A
Horse
transmembrane protein 185A
Publication Statistics
PubMed Score 37.29
PubMed score by year
PubTator Score 145.30
PubTator score by year
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Related Publications
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PMID
Year
Title