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Tdark
TMEM183A
Transmembrane protein 183A

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367242
  • ENSP00000356211
  • ENSG00000163444

Symbol
  • C1orf37
  • C1orf37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
histone modification site profile
0.84
virus perturbation
0.83
transcription factor binding site profile
0.74
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
GPN1
Tbio
Family:  Enzyme
Novelty:  0.06883613
p_int:  0.999999742
p_ni:  2.35e-7
p_wrong:  2.3e-8
Data Source:  BioPlex
ACTN3
Tbio
Novelty:  0.00375035
p_int:  0.99997705
p_ni:  0.00002067
p_wrong:  0.00000228
Data Source:  BioPlex
SYP
Tbio
Novelty:  0.00021543
p_int:  0.999895254
p_ni:  0.000099867
p_wrong:  0.000004878
Score:  0.319
Data Source:  BioPlex,STRINGDB
IFNLR1
Tbio
Novelty:  0.01990628
p_int:  0.998887307
p_ni:  0.000659176
p_wrong:  0.000453517
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.998400874
p_ni:  0.001384468
p_wrong:  0.000214658
Data Source:  BioPlex
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.997901357
p_ni:  0.00093788
p_wrong:  0.001160762
Data Source:  BioPlex
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.923109722
p_ni:  0.076890278
Data Source:  BioPlex
HSF2BP
Tbio
Novelty:  0.18601995
Score:  0.81
Data Source:  STRINGDB
VRK2
Tbio
Family:  Kinase
Novelty:  0.03300582
Score:  0.756
Data Source:  STRINGDB
AP5Z1
Tbio
Family:  TF
Novelty:  0.14368974
Score:  0.694
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.1
92.2
mean platelet volume
3
1
3
75.7
childhood onset asthma
2
1
0
1.1
73.5
3
3
0
1
67.1
ganglion cell inner plexiform layer thickness measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.2
mean platelet volume
3
75.7
childhood onset asthma
0
1.1
73.5
0
1
67.1
ganglion cell inner plexiform layer thickness measurement
1
26.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 183A
VGNC:10930
457636
Mouse
MGI:1914729
57439
Rat
RGD:1309892
289034
Dog
transmembrane protein 183A
VGNC:53838
479994
Horse
transmembrane protein 183A
100065104
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 183A
Mouse
Rat
Dog
transmembrane protein 183A
Horse
transmembrane protein 183A
Publication Statistics
PubMed Score 2.39
PubMed score by year
PubTator Score 2.20
PubTator score by year
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Related Publications
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PMID
Year
Title