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Tdark
TMEM178A
Transmembrane protein 178A

Protein Summary
Description
Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281961
  • ENSP00000281961
  • ENSG00000152154
  • ENST00000618232
  • ENSP00000477622

Symbol
  • TMEM178
  • TMEM178
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
tissue sample
0.7
cell type or tissue
0.61
transcription factor
0.57
PubMedID
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
DHX57
Tdark
Family:  Enzyme
Novelty:  0.8244078
Score:  0.715
Data Source:  STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
Score:  0.694
Data Source:  STRINGDB
FAIM2
Tbio
Novelty:  0.02444421
Score:  0.657
Data Source:  STRINGDB
TMEM179
Tdark
Novelty:  2.21288966
Score:  0.64
Data Source:  STRINGDB
TMEM88B
Tdark
Novelty:  1.83653775
Score:  0.626
Data Source:  STRINGDB
FAM189A1
Tdark
Novelty:  0.94298311
Score:  0.623
Data Source:  STRINGDB
TMEM59L
Tbio
Novelty:  0.22745646
Score:  0.623
Data Source:  STRINGDB
TMEM130
Tdark
Novelty:  1.39618601
Score:  0.621
Data Source:  STRINGDB
FAM171B
Tdark
Novelty:  0.38456365
Score:  0.62
Data Source:  STRINGDB
FAM19A1
Tbio
Novelty:  0.27533335
Score:  0.596
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
100
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
100
7.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 178A
VGNC:397
735970
Mouse
MGI:1915277
68027
Rat
RGD:1303057
362691
Dog
transmembrane protein 178A
VGNC:47504
475737
Cow
transmembrane protein 178A
VGNC:36003
538491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 178A
Mouse
Rat
Dog
transmembrane protein 178A
Cow
transmembrane protein 178A
Publication Statistics
PubMed Score 3.28
PubMed score by year
PubTator Score 0.42
PubTator score by year
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Related Publications
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PMID
Year
Title