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Tdark
TMEM159
Promethin

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233047
  • ENSP00000233047
  • ENSG00000011638
  • ENST00000261388
  • ENSP00000261388
  • ENST00000451578
  • ENSP00000409879
  • ENST00000572599
  • ENSP00000460687
  • ENST00000638934
  • ENSP00000492501
  • ENSG00000283997
  • ENST00000639177
  • ENSP00000492842
  • ENST00000640188
  • ENSP00000491056
  • ENST00000640514
  • ENSP00000492164
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.78
disease perturbation
0.62
tissue sample
0.57
tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
MB21D2
Tdark
Novelty:  0.48908631
p_int:  0.99999995
p_ni:  5e-8
Data Source:  BioPlex
CC2D1A
Tbio
Novelty:  0.01970021
p_int:  0.999973509
p_ni:  0.00002647
p_wrong:  2.1e-8
Data Source:  BioPlex
MTMR6
Tbio
Family:  Enzyme
Novelty:  0.13067072
p_int:  0.999964083
p_ni:  0.000035891
p_wrong:  2.6e-8
Data Source:  BioPlex
ZNF518A
Tdark
Novelty:  1.30119746
p_int:  0.999942655
p_ni:  0.000057345
Data Source:  BioPlex
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.999889572
p_ni:  0.000110426
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
ENDOD1
Tdark
Family:  Enzyme
Novelty:  0.26430864
p_int:  0.999801813
p_ni:  0.000198174
p_wrong:  1.3e-8
Data Source:  BioPlex
CLEC14A
Tbio
Novelty:  0.03231666
p_int:  0.999785628
p_ni:  0.00021437
p_wrong:  2e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.99963129
p_ni:  0.000349774
p_wrong:  0.000018936
Data Source:  BioPlex
RNF26
Tbio
Novelty:  0.40088751
p_int:  0.999280382
p_ni:  1.7e-8
p_wrong:  0.000719601
Data Source:  BioPlex
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.998953787
p_ni:  0.001040695
p_wrong:  0.000005518
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 159
VGNC:5938
742443
Macaque
transmembrane protein 159
697344
Mouse
MGI:1925752
233806
Rat
RGD:727895
378467
Dog
transmembrane protein 159
VGNC:47487
479819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 159
Macaque
transmembrane protein 159
Mouse
Rat
Dog
transmembrane protein 159
Publication Statistics
PubMed Score 4.02
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title