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Tdark
TMEM154
Transmembrane protein 154

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304385
  • ENSP00000302144
  • ENSG00000170006
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
histone modification site profile
0.75
gene perturbation
0.71
tissue sample
0.63
transcription factor binding site profile
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.999999544
p_ni:  4.56e-7
Data Source:  BioPlex
OPA3
Tbio
Novelty:  0.01508376
p_int:  0.99999813
p_ni:  0.000001865
p_wrong:  6e-9
Data Source:  BioPlex
GIT2
Tbio
Family:  Enzyme
Novelty:  0.01530665
p_int:  0.999913781
p_ni:  0.000086218
p_wrong:  2e-9
Data Source:  BioPlex
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.999868115
p_ni:  0.000131885
Data Source:  BioPlex
ARHGEF6
Tbio
Novelty:  0.02162737
p_int:  0.999765295
p_ni:  0.00022076
p_wrong:  0.000013945
Data Source:  BioPlex
TMEM175
Tbio
Novelty:  0.07230682
p_int:  0.997823158
p_ni:  2.28e-7
p_wrong:  0.002176614
Data Source:  BioPlex
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
p_int:  0.996861381
p_ni:  0.003138618
p_wrong:  1e-9
Data Source:  BioPlex
TMEM19
Tdark
Novelty:  1.22010943
p_int:  0.978460568
p_ni:  1.7e-8
p_wrong:  0.021539415
Data Source:  BioPlex
CHSY1
Tbio
Family:  Enzyme
Novelty:  0.03515909
p_int:  0.974586352
p_ni:  0.025410597
p_wrong:  0.000003051
Data Source:  BioPlex
PTCD2
Tdark
Novelty:  0.23529342
p_int:  0.926387891
p_ni:  0.073612075
p_wrong:  3.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
3
1.1
90.8
red blood cell distribution width
4
2
4
82.7
mean platelet volume
1
1
1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
90.8
red blood cell distribution width
4
82.7
mean platelet volume
1
63.4
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2444725
320782
Rat
RGD:1563262
361972
Dog
transmembrane protein 154
VGNC:47485
612458
Horse
transmembrane protein 154
VGNC:50784
100629231
Pig
transmembrane protein 154
100627594
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 154
Horse
transmembrane protein 154
Pig
transmembrane protein 154
Publication Statistics
PubMed Score 17.65
PubMed score by year
PubTator Score 1.49
PubTator score by year
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Related Publications
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PMID
Year
Title