You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TMEM150C
Transmembrane protein 150C

Protein Summary
Description
Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception. This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000449862
  • ENSP00000403438
  • ENSG00000249242
  • ENST00000515780
  • ENSP00000420919

Symbol
  • TTN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
tissue sample
0.63
histone modification site profile
0.59
microRNA
0.48
transcription factor perturbation
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
MAPK4
Tbio
Family:  Kinase
Novelty:  0.0223868
Score:  0.656
Data Source:  STRINGDB
PMEPA1
Tbio
Novelty:  0.02488769
Score:  0.624
Data Source:  STRINGDB
TMEM221
Tdark
Novelty:  6.39119451
Score:  0.601
Data Source:  STRINGDB
ARL4D
Tbio
Family:  Enzyme
Novelty:  0.13254344
Score:  0.586
Data Source:  STRINGDB
TMEM212
Tdark
Novelty:  0.94290731
Score:  0.583
Data Source:  STRINGDB
TMEM132E
Tdark
Novelty:  0.27039617
Score:  0.582
Data Source:  STRINGDB
TMEM211
Tdark
Novelty:  6.51386952
Score:  0.572
Data Source:  STRINGDB
GPR137C
Tdark
Novelty:  3.30248948
Score:  0.564
Data Source:  STRINGDB
TET3
Tbio
Family:  Enzyme
Novelty:  0.00557444
Score:  0.549
Data Source:  STRINGDB
TMEM171
Tdark
Novelty:  2.00247773
Score:  0.545
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
6
6
6
95.7
lymphocyte count
7
6
7
95.4
leukocyte count
5
3
5
86.1
eosinophil count
4
2
4
79.4
myeloid white cell count
3
2
3
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
6
95.7
lymphocyte count
7
95.4
leukocyte count
5
86.1
eosinophil count
4
79.4
myeloid white cell count
3
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3041258
231503
Rat
RGD:1306105
360916
Dog
transmembrane protein 150C
VGNC:47483
608621
Horse
transmembrane protein 150C
VGNC:24208
100051954
Cow
transmembrane protein 150C
VGNC:35982
534560
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 150C
Horse
transmembrane protein 150C
Cow
transmembrane protein 150C
Publication Statistics
PubMed Score 10.85
PubMed score by year
PubTator Score 3.11
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title