Tbio TMEM150A Transmembrane protein 150A

Protein Summary

Description

Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).

Uniprot Accession IDs

• Q86TG1
• A8K764
• B7WPQ9
• D6W5L2
• Q8N2R6

Gene Name

• TMEM150A

Ensembl ID

• ENST00000306353
• ENSP00000302715
• ENSG00000168890
• ENST00000334462
• ENSP00000334708
• ENST00000409668
• ENSP00000387292

Symbol

• TMEM150
• TTN1
• TM6P1
• TMEM150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74
transcription factor perturbation	0.61
tissue sample	0.59
virus perturbation	0.59
cell type or tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.99   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.99   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0