Tbio TMEM150A Transmembrane protein 150A

Protein Summary

Description

Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also play a role in fasting-induced catabolism (By similarity).

Uniprot Accession IDs

• Q86TG1
• A8K764
• B7WPQ9
• D6W5L2
• Q8N2R6

Gene Name

• TMEM150A

Ensembl ID

• ENST00000306353
• ENSP00000302715
• ENSG00000168890
• ENST00000334462
• ENSP00000334708
• ENST00000409668
• ENSP00000387292

Symbol

• TMEM150
• TTN1
• TM6P1
• TMEM150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74
transcription factor perturbation	0.61
tissue sample	0.59
virus perturbation	0.59
cell type or tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.75   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.75   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

ACOX3

Tchem

Family:  Enzyme

Novelty:  0.04077258

p_int:  0.999998266

p_ni:  0.00000144

p_wrong:  2.94e-7

Score:  0.252

Data Source:  BioPlex,STRINGDB

CCNT1

Tchem

Novelty:  0.00526848

p_int:  0.98491329

p_ni:  0.015086694

p_wrong:  1.6e-8

Score:  0.196

Data Source:  BioPlex,STRINGDB

YY1

Tbio

Family:  TF

Novelty:  0.00120891

p_int:  0.973999973

p_ni:  0.025998607

p_wrong:  0.00000142

Score:  0.295

Data Source:  BioPlex,STRINGDB

MIS18A

Tbio

Novelty:  0.08143008

p_int:  0.971060754

p_ni:  0.028934341

p_wrong:  0.000004904

Score:  0.295

Data Source:  BioPlex,STRINGDB

GOSR1

Tbio

Novelty:  0.03139481

p_int:  0.908785829

p_ni:  0.091212529

p_wrong:  0.000001642

Score:  0.189

Data Source:  BioPlex,STRINGDB

HELLS

Tbio

Family:  Enzyme

Novelty:  0.01348077

p_int:  0.855613703

p_ni:  0.144386293

p_wrong:  4e-9

Score:  0.295

Data Source:  BioPlex,STRINGDB

C2orf68

Tdark

Novelty:  0.7947239

Score:  0.83

Data Source:  STRINGDB

USP39

Tbio

Novelty:  0.03914006

Score:  0.786

Data Source:  STRINGDB

PSD4

Tbio

Novelty:  0.0674237

Score:  0.723

Data Source:  STRINGDB

RNF144B

Tbio

Family:  Enzyme

Novelty:  0.02487971

Score:  0.685

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (2)

Processes (4)

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GO Term	Evidence	Assigned by
integral component of plasma membrane	Inferred from Direct Assay (IDA)	UniProtKB
lysosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (20)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	7	6	4	1.1	94.9
prostate carcinoma	EFO_0001663	6	4	1	1.1	90
serum gamma-glutamyl transferase measurement	EFO_0004532	2	3	3		81.1
myocardial infarction	EFO_0000612	3	2	0	1.1	69.6
eosinophil count	EFO_0004842	3	1	3		62.8

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5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	4	1.1	94.9
prostate carcinoma	EFO_0001663	1	1.1	90
serum gamma-glutamyl transferase measurement	EFO_0004532	3		81.1
myocardial infarction	EFO_0000612	0	1.1	69.6
eosinophil count	EFO_0004842	3		62.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
albuminuria
basophil count
breast carcinoma
cancer
coronary artery disease
eosinophil count
eosinophil percentage of leukocytes
myocardial infarction
ovarian carcinoma
platelet count

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 150A	VGNC:410	459367
Mouse	transmembrane protein 150A	MGI:2385244	232086
Rat	transmembrane protein 150A	RGD:619998	245966
Dog	transmembrane protein 150A	VGNC:47481	483080
Horse	transmembrane protein 150A	VGNC:24206	100053096

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 150A
Mouse	transmembrane protein 150A
Rat	transmembrane protein 150A
Dog	transmembrane protein 150A
Horse	transmembrane protein 150A

Publication Statistics

PubMed Score 6.75

PubMed score by year

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PubTator Score 1.00

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title