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Tbio
TMEM14B
Transmembrane protein 14B

Protein Summary
Description
Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379530
  • ENSP00000368845
  • ENSG00000137210
  • ENST00000379542
  • ENSP00000368858
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
tissue sample
0.66
histone modification site profile
0.65
tissue
0.58
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
NDUFAB1
Tclin
Novelty:  0.00190242
Score:  0.682
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.667
Data Source:  STRINGDB
TTC16
Tdark
Novelty:  14.55737705
Score:  0.647
Data Source:  STRINGDB
RTRAF
Tbio
Novelty:  0.03996206
Score:  0.638
Data Source:  STRINGDB
SELENOF
Tbio
Novelty:  0.01883734
Score:  0.599
Data Source:  STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.594
Data Source:  STRINGDB
KRCC1
Tbio
Novelty:  0.27113087
Score:  0.58
Data Source:  STRINGDB
TMEM14C
Tdark
Novelty:  0.10707234
Score:  0.576
Data Source:  STRINGDB
TEX261
Tdark
Novelty:  0.66416503
Score:  0.557
Data Source:  STRINGDB
ENOSF1
Tbio
Family:  Enzyme
Novelty:  0.05583478
Score:  0.523
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
3
3
94.2
calcium measurement
2
1
2
46.7
estradiol measurement
2
1
1
5.8
32.2
age at menarche
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
3
94.2
calcium measurement
2
46.7
estradiol measurement
1
5.8
32.2
age at menarche
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 14B
VGNC:12718
746566
Xenopus
transmembrane protein 14C
XB-GENE-876311
779878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 14B
Xenopus
transmembrane protein 14C
Publication Statistics
PubMed Score 1.80
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title