Tbio TMEM14A Transmembrane protein 14A

Protein Summary

Description

Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.

Uniprot Accession IDs

• Q9Y6G1
• B2R552

Gene Name

• TMEM14A

Ensembl ID

• ENST00000211314
• ENSP00000211314
• ENSG00000096092

Symbol

• C6orf73
• PTD011
• C6orf73

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
transcription factor perturbation	0.74
kinase perturbation	0.71
transcription factor binding site profile	0.6
histone modification site profile	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.62   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.62   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0