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Tbio
TMEM147
Transmembrane protein 147

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222284
  • ENSP00000222284
  • ENSG00000105677
  • ENST00000392204
  • ENSP00000376040

Symbol
  • NIFIE14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.96
histone modification site profile
0.91
co-expressed gene
0.76
transcription factor perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999998412
p_ni:  0.000001525
p_wrong:  6.2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.990210292
p_ni:  0.000621305
p_wrong:  0.009168403
Score:  0.179
Data Source:  BioPlex,STRINGDB
NOMO2
Tdark
Novelty:  0.17781596
Score:  0.989
Data Source:  STRINGDB
NCLN
Tbio
Novelty:  0.10851333
Score:  0.985
Data Source:  STRINGDB
EMG1
Tbio
Family:  Enzyme
Novelty:  0.00462566
Score:  0.886
Data Source:  STRINGDB
PFDN5
Tbio
Novelty:  0.07673574
Score:  0.875
Data Source:  STRINGDB
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
Score:  0.737
Data Source:  STRINGDB
YIPF6
Tdark
Novelty:  0.04316252
Score:  0.737
Data Source:  STRINGDB
IER3IP1
Tbio
Novelty:  0.07401881
Score:  0.72
Data Source:  STRINGDB
HAUS5
Tbio
Novelty:  0.99720546
Score:  0.704
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
3
86.2
hemoglobin measurement
3
3
3
76.8
serum albumin measurement
1
1
1
69.8
red blood cell distribution width
2
2
2
67.1
serum alanine aminotransferase measurement
2
1
1
6.9
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
86.2
hemoglobin measurement
3
76.8
serum albumin measurement
1
69.8
red blood cell distribution width
2
67.1
serum alanine aminotransferase measurement
1
6.9
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 147
VGNC:13085
455952
Macaque
transmembrane protein 147
709568
Mouse
MGI:1915011
69804
Rat
RGD:1304706
292792
Dog
transmembrane protein 147
VGNC:47480
476482
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 147
Macaque
transmembrane protein 147
Mouse
Rat
Dog
transmembrane protein 147
Publication Statistics
PubMed Score 5.23
PubMed score by year
PubTator Score 0.57
PubTator score by year
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Related Publications
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PMID
Year
Title