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Tdark
TMEM145
Transmembrane protein 145

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301204
  • ENSP00000301204
  • ENSG00000167619
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.61
cell line
0.59
histone modification site profile
0.51
PubMedID
0.51
tissue
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.83   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
ZNF574
Tdark
Family:  TF
Novelty:  2.72596185
Score:  0.824
Data Source:  STRINGDB
PAFAH1B3
Tbio
Family:  Enzyme
Novelty:  0.10517347
Score:  0.77
Data Source:  STRINGDB
ETHE1
Tbio
Family:  Enzyme
Novelty:  0.01397214
Score:  0.745
Data Source:  STRINGDB
TOMM40L
Tdark
Novelty:  0.24691216
Score:  0.716
Data Source:  STRINGDB
PRR19
Tdark
Novelty:  0.52254246
Score:  0.709
Data Source:  STRINGDB
CEACAM16
Tbio
Novelty:  0.11153655
Score:  0.707
Data Source:  STRINGDB
CNFN
Tdark
Novelty:  0.15365561
Score:  0.703
Data Source:  STRINGDB
ATP1A3
Tclin
Family:  Transporter
Novelty:  0.00485594
Score:  0.695
Data Source:  STRINGDB
TMEM179
Tdark
Novelty:  2.21288966
Score:  0.635
Data Source:  STRINGDB
FAM171B
Tdark
Novelty:  0.38456365
Score:  0.631
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
82.2
monocyte count
3
1
3
68.9
1
1
1
66.7
leukocyte count
2
2
2
59.3
corneal resistance factor
1
1
1
56.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
82.2
monocyte count
3
68.9
1
66.7
leukocyte count
2
59.3
corneal resistance factor
1
56.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 145
VGNC:13081
740584
Macaque
transmembrane protein 145
709268
Mouse
MGI:3607779
330485
Rat
RGD:1595911
292722
Horse
transmembrane protein 145
VGNC:51086
100147203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 145
Macaque
transmembrane protein 145
Mouse
Rat
Horse
transmembrane protein 145
Publication Statistics
PubMed Score 0.83
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title