You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TMEM143
Transmembrane protein 143

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293261
  • ENSP00000293261
  • ENSG00000161558
  • ENST00000377431
  • ENSP00000366649
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.81
transcription factor
0.73
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.999994896
p_ni:  0.000005072
p_wrong:  3.2e-8
Data Source:  BioPlex
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999971456
p_ni:  0.00002802
p_wrong:  5.25e-7
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999739471
p_ni:  0.000117246
p_wrong:  0.000143284
Data Source:  BioPlex
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.997808195
p_ni:  0.002065264
p_wrong:  0.000126541
Data Source:  BioPlex
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
p_int:  0.99141606
p_ni:  0.008567507
p_wrong:  0.000016432
Score:  0.161
Data Source:  BioPlex,STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
p_int:  0.989418744
p_ni:  0.010544919
p_wrong:  0.000036336
Score:  0.169
Data Source:  BioPlex,STRINGDB
TMEM186
Tdark
Novelty:  0.59951294
Score:  0.782
Data Source:  STRINGDB
ARMC4
Tbio
Novelty:  0.17860406
Score:  0.741
Data Source:  STRINGDB
IQCE
Tdark
Novelty:  0.24800472
Score:  0.67
Data Source:  STRINGDB
PHYHIPL
Tdark
Family:  Enzyme
Novelty:  1.63617414
Score:  0.595
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
31.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 143
VGNC:2226
456178
Macaque
transmembrane protein 143
717890
Mouse
MGI:1917459
70209
Rat
RGD:1305013
308593
Dog
transmembrane protein 143
VGNC:47478
612068
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 143
Macaque
transmembrane protein 143
Mouse
Rat
Dog
transmembrane protein 143
Publication Statistics
PubMed Score 0.38
PubMed score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title